AMN 082 dihydrochloride | Tocris Bioscience 2385/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AMN 082 dihydrochloride

catalog :

2385/10

quantity :

10 mg (also 50 mg)

price :

155 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Shao L, Liu Y, Xiao J, Wang Q, Liu F, Ding J. Activating metabotropic glutamate receptor‑7 attenuates visceral hypersensitivity in neonatal maternally separated rats. Int J Mol Med. 2019;43:761-770 pubmed publisher
Jantas D, Lech T, Gołda S, Pilc A, Lasoń W. New evidences for a role of mGluR7 in astrocyte survival: Possible implications for neuroprotection. Neuropharmacology. 2018;141:223-237 pubmed publisher
Broadstock M, Austin P, Betts M, Duty S. Antiparkinsonian potential of targeting group III metabotropic glutamate receptor subtypes in the rodent substantia nigra pars reticulata. Br J Pharmacol. 2012;165:1034-45 pubmed publisher

image

image 1 :

Cat.No. 2385 - AMN 082 dihydrochloride C28H28N2.2HCl CAS No. 97075-46-2

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

2385

SKU :

2385/10

product name :

AMN 082 dihydrochloride

Description :

Selective mGlu7 agonist

target :

Group III mGluR Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

465.45

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AMN 082 dihydrochloride is a the first selective mGlu7 agonist. Potently inhibits cAMP accumulation and stimulates GTP S binding in recombinant cells and on membranes expressing mGlu7 (EC50 = 64 - 290 nM). Selective over other mGluR subtypes and selected ionotropic glutamate receptors up to 10 u M. Acts via a novel allosteric site and is orally active and brain penetrant. Reduces haloperidol-induced catalepsy in rats. . View important information regarding the usage of AMN 082 dihydrochloride .

extended description :

Selective mGlu7 agonist

chemical name text :

N,N -Bis(diphenylmethyl)-1,2-ethanediamine dihydrochloride

formula :

C 28 H 28 N 2 .2HCl

formula text :

C28H28N2.2HCl

cas num :

97075-46-2

USD :

155 USD

product details :

Selective mGlu7 agonist

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage