Bryostatin 1 | Tocris Bioscience 2383/10U product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Bryostatin 1

catalog :

2383/10U

quantity :

10 ug

price :

237 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Schaffer T, Smith J, Cook E, Phan T, Margolis S. PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5. Cell Rep. 2018;25:2470-2483.e8 pubmed publisher
Marsden M, Wu X, Navab S, Loy B, Schrier A, DeChristopher B, et al. Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents. Virology. 2018;520:83-93 pubmed publisher
Kornberg M, Smith M, Shirazi H, Calabresi P, Snyder S, Kim P. Bryostatin-1 alleviates experimental multiple sclerosis. Proc Natl Acad Sci U S A. 2018;115:2186-2191 pubmed publisher
Visavadiya N, Keasey M, Razskazovskiy V, Banerjee K, Jia C, Lovins C, et al. Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Commun Signal. 2016;14:32 pubmed
Lin Y, Wang H, Huang D, Hsieh P, Lin M, Chou C, et al. Neuronal Splicing Regulator RBFOX3 (NeuN) Regulates Adult Hippocampal Neurogenesis and Synaptogenesis. PLoS ONE. 2016;11:e0164164 pubmed publisher
Park Y, Wood G, Kastner D, Chae J. Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol. 2016;17:914-21 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

2383

SKU :

2383/10U

product name :

Bryostatin 1

Description :

Protein kinase C activator

target :

Protein Kinase C Activators

category :

Small Molecules

unit size :

10 ug

purity :

98%

observed molecular weight :

905.04

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Bryostatin 1 is a protein kinase C (PKC) activator that binds with high affinity (Ki = 1.35 nM). Initially activates and subsequently induces downregulation of PKC isozymes. Sensitizes tumor cells to cytotoxic effects of anticancer agents. Restores hippocampal synapses and spatial learning and memory in an in vivo model of fragile X syndrome.

extended description :

Protein kinase C activator

chemical name text :

(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl-(2E, 4E)-2,

formula :

C 47 H 68 O 17

formula text :

C47H68O17

cas num :

83314-01-6

USD :

237 USD

product details :

Protein kinase C activator

alt names :

NSC 339555

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage