T 0901317 | Tocris Bioscience 2373 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

T 0901317

catalog :

2373

quantity :

10 mg (also 50 mg)

price :

97 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
El Kasmi K, Vue P, Anderson A, Devereaux M, Ghosh S, Balasubramaniyan N, et al. Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis. Nat Commun. 2018;9:1393 pubmed publisher
Herold M, Breuer J, Hucke S, Knolle P, Schwab N, Wiendl H, et al. Liver X receptor activation promotes differentiation of regulatory T cells. PLoS ONE. 2017;12:e0184985 pubmed publisher
Bonney S, Siegenthaler J. Differential Effects of Retinoic Acid Concentrations in Regulating Blood-Brain Barrier Properties. Eneuro. 2017;4: pubmed publisher
Paterniti I, Campolo M, Siracusa R, Cordaro M, Di Paola R, Calabrese V, et al. Liver X receptors activation, through TO901317 binding, reduces neuroinflammation in Parkinson's disease. PLoS ONE. 2017;12:e0174470 pubmed publisher
Kim H. The transcription cofactor CRTC1 protects from aberrant hepatic lipid accumulation. Sci Rep. 2016;6:37280 pubmed publisher
Singh S, Kang L, Nawrocki A, Zhou D, Wu M, Previs S, et al. The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys. PLoS ONE. 2016;11:e0164133 pubmed publisher
Candelaria N, Addanki S, Zheng J, Nguyen Vu T, Karaboga H, Dey P, et al. Antiproliferative effects and mechanisms of liver X receptor ligands in pancreatic ductal adenocarcinoma cells. PLoS ONE. 2014;9:e106289 pubmed publisher
Wahlang B, Falkner K, Clair H, Al Eryani L, Prough R, States J, et al. Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture. Toxicol Sci. 2014;140:283-97 pubmed publisher

product information

brand :

Tocris

master code :

2373

SKU :

2373/10

product name :

T 0901317

description :

Potent liver X receptor (LXR) agonist; also CAR inverse agonist

target :

LXR-like Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

481.33

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, high affinity liver X receptor (LXR) agonist (EC50 ~ 50 nM, Kd values are 7 and 22 nM for LXR- and LXR- respectively). Upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism. Decreases amyloid- production in primary neurons in vitro . Displays an EC50 of ~ 5 u M for activation of bile acid farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand chenodeoxycholic acid. Also exhibits inverse agonist activity at constitutive androstane receptors (CAR).

catalog number base :

2373

product keywords :

Potent liver X receptor LXR agonists FXR Receptors Liver Farnesoid LXR-like T0901317 LXR-like Receptors Constitutive Androstane Receptor 2373,

extended description :

Potent liver X receptor (LXR) agonist; also CAR inverse agonist

chemical name text :

N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzenesulfonamide

formula :

C 17 H 12 F 9 NO 3 S

formula text :

C17H12F9NO3S

cas num :

293754-55-9

2020 USD :

2021 USD :

97 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage