T 0901317 | Tocris Bioscience 2373/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

T 0901317

catalog :

2373/10

quantity :

10 mg (also 50 mg)

price :

126 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
El Kasmi K, Vue P, Anderson A, Devereaux M, Ghosh S, Balasubramaniyan N, et al. Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis. Nat Commun. 2018;9:1393 pubmed publisher
Herold M, Breuer J, Hucke S, Knolle P, Schwab N, Wiendl H, et al. Liver X receptor activation promotes differentiation of regulatory T cells. PLoS ONE. 2017;12:e0184985 pubmed publisher
Bonney S, Siegenthaler J. Differential Effects of Retinoic Acid Concentrations in Regulating Blood-Brain Barrier Properties. Eneuro. 2017;4: pubmed publisher
Paterniti I, Campolo M, Siracusa R, Cordaro M, Di Paola R, Calabrese V, et al. Liver X receptors activation, through TO901317 binding, reduces neuroinflammation in Parkinson's disease. PLoS ONE. 2017;12:e0174470 pubmed publisher
Kim H. The transcription cofactor CRTC1 protects from aberrant hepatic lipid accumulation. Sci Rep. 2016;6:37280 pubmed publisher
Singh S, Kang L, Nawrocki A, Zhou D, Wu M, Previs S, et al. The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys. PLoS ONE. 2016;11:e0164133 pubmed publisher
Daffu G, Shen X, Senatus L, Thiagarajan D, Abedini A, Hurtado del Pozo C, et al. RAGE Suppresses ABCG1-Mediated Macrophage Cholesterol Efflux in Diabetes. Diabetes. 2015;64:4046-60 pubmed publisher
Candelaria N, Addanki S, Zheng J, Nguyen Vu T, Karaboga H, Dey P, et al. Antiproliferative effects and mechanisms of liver X receptor ligands in pancreatic ductal adenocarcinoma cells. PLoS ONE. 2014;9:e106289 pubmed publisher
Wahlang B, Falkner K, Clair H, Al Eryani L, Prough R, States J, et al. Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture. Toxicol Sci. 2014;140:283-97 pubmed publisher

product information

brand :

Tocris

catalog number base :

2373

SKU :

2373/10

product name :

T 0901317

units size :

10 mg (also 50 mg)

description :

Potent liver X receptor (LXR) agonist; also CAR inverse agonist

target :

LXR-like Receptor Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

481.33

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

T 0901317 is a potent, high affinity liver X receptor (LXR) agonist (EC50 ~ 50 nM, Kd values are 7 and 22 nM for LXR- and LXR- respectively). Upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism. Decreases amyloid- production in primary neurons in vitro . Displays an EC50 of ~ 5 u M for activation of bile acid farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand chenodeoxycholic acid. Also exhibits inverse agonist activity at constitutive androstane receptors (CAR).

top caption :

Potent liver X receptor (LXR) agonist; also CAR inverse agonist

extended description :

Potent liver X receptor (LXR) agonist; also CAR inverse agonist

chemical name text :

N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzenesulfonamide

formula :

C17H12F9NO3S

formula text :

C17H12F9NO3S

cas num :

293754-55-9

USD :

126 USD

product details :

Potent liver X receptor (LXR) agonist; also CAR inverse agonist

storage :

Store at +4Â°C

more info or order :

Tocris Bioscience product webpage