product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Dihydro-b-erythroidine hydrobromide
catalog :
2349/10
quantity :
10 mg (also 50 mg)
price :
281 USD
more info or order :
citations: 33
Reference
Dorst M, Tokarska A, Zhou M, Lee K, Stagkourakis S, Broberger C, et al. Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner. Nat Commun. 2020;11:5113 pubmed publisher
Rufener L, Kaur K, Sarr A, Aaen S, Horsberg T. Nicotinic acetylcholine receptors: Ex-vivo expression of functional, non-hybrid, heteropentameric receptors from a marine arthropod, Lepeophtheirus salmonis. PLoS Pathog. 2020;16:e1008715 pubmed publisher
Huang X, Rangel M, Briggman K, Wei W. Neural mechanisms of contextual modulation in the retinal direction selective circuit. Nat Commun. 2019;10:2431 pubmed publisher
Brodnik Z, Batra A, Oleson E, Espana R. Local GABAA Receptor-Mediated Suppression of Dopamine Release within the Nucleus Accumbens. ACS Chem Neurosci. 2019;10:1978-1985 pubmed publisher
Zhang Y, Reynolds J, Cragg S. Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with Dopamine Modulation. Neuron. 2018;98:918-925.e3 pubmed publisher
Lozovaya N, Eftekhari S, Cloarec R, Gouty Colomer L, Dufour A, Riffault B, et al. GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease. Nat Commun. 2018;9:1422 pubmed publisher
Kiguchi N, Kobayashi D, Saika F, Matsuzaki S, Kishioka S. Inhibition of peripheral macrophages by nicotinic acetylcholine receptor agonists suppresses spinal microglial activation and neuropathic pain in mice with peripheral nerve injury. J Neuroinflammation. 2018;15:96 pubmed publisher
Kutlu M, Tumolo J, Cann C, Gould T. Differential effects of α4β2 nicotinic receptor antagonists and partial-agonists on contextual fear extinction in male C57BL/6 mice. Psychopharmacology (Berl). 2018;235:1211-1219 pubmed publisher
Hurtado Zavala J, Ramachandran B, Ahmed S, Halder R, Bolleyer C, Awasthi A, et al. TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus. Nat Commun. 2017;8:15878 pubmed publisher
Govind A, Vallejo Y, Stolz J, Yan J, Swanson G, Green W. Selective and regulated trapping of nicotinic receptor weak base ligands and relevance to smoking cessation. elife. 2017;6: pubmed publisher
Assous M, Kaminer J, Shah F, Garg A, Koos T, Tepper J. Differential processing of thalamic information via distinct striatal interneuron circuits. Nat Commun. 2017;8:15860 pubmed publisher
Jareczek F, White S, Hammond D. Plasticity in Brainstem Mechanisms of Pain Modulation by Nicotinic Acetylcholine Receptors in the Rat. Eneuro. 2017;4: pubmed publisher
Sternfeld M, Hinckley C, Moore N, Pankratz M, Hilde K, Driscoll S, et al. Speed and segmentation control mechanisms characterized in rhythmically-active circuits created from spinal neurons produced from genetically-tagged embryonic stem cells. elife. 2017;6: pubmed publisher
Mamaligas A, Cai Y, Ford C. Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission. Sci Rep. 2016;6:37834 pubmed publisher
Herman A, Ortiz Guzman J, Kochukov M, Herman I, Quast K, Patel J, et al. A cholinergic basal forebrain feeding circuit modulates appetite suppression. Nature. 2016;538:253-256 pubmed publisher
Kunisawa N, Iha H, Shimizu S, Tokudome K, Mukai T, Kinboshi M, et al. Nicotine evokes kinetic tremor by activating the inferior olive via α7 nicotinic acetylcholine receptors. Behav Brain Res. 2016;314:173-80 pubmed publisher
Garcia Bereguiain M, Gonzalez Islas C, Lindsly C, Wenner P. Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo. J Neurosci. 2016;36:7268-82 pubmed publisher
Stouffer M, Woods C, Patel J, Lee C, Witkovsky P, Bao L, et al. Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward. Nat Commun. 2015;6:8543 pubmed publisher
Bader S, Diener M. Novel aspects of cholinergic regulation of colonic ion transport. Pharmacol Res Perspect. 2015;3:e00139 pubmed publisher
Morrie R, Feller M. An Asymmetric Increase in Inhibitory Synapse Number Underlies the Development of a Direction Selective Circuit in the Retina. J Neurosci. 2015;35:9281-6 pubmed publisher
Ngolab J, Liu L, Zhao Shea R, Gao G, Gardner P, Tapper A. Functional Upregulation of α4* Nicotinic Acetylcholine Receptors in VTA GABAergic Neurons Increases Sensitivity to Nicotine Reward. J Neurosci. 2015;35:8570-8 pubmed publisher
Saunders A, Granger A, Sabatini B. Corelease of acetylcholine and GABA from cholinergic forebrain neurons. elife. 2015;4: pubmed publisher
Dilger E, Krahe T, Morhardt D, Seabrook T, Shin H, Guido W. Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement. J Neurosci. 2015;35:3652-62 pubmed publisher
Elgueta C, Vielma A, Palacios A, Schmachtenberg O. Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells. Front Cell Neurosci. 2015;9:6 pubmed publisher
Yorgason J, Rose J, McIntosh J, Ferris M, Jones S. Greater ethanol inhibition of presynaptic dopamine release in C57BL/6J than DBA/2J mice: Role of nicotinic acetylcholine receptors. Neuroscience. 2015;284:854-64 pubmed publisher
Dobryakova Y, Gurskaya O, Markevich V. Administration of nicotinic receptor antagonists during the period of memory consolidation affects passive avoidance learning and modulates synaptic efficiency in the CA1 region in vivo. Neuroscience. 2015;284:865-71 pubmed publisher
Kiss T, Krajcs N, Pirger Z, Hernádi L. Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle. PLoS ONE. 2014;9:e109538 pubmed publisher
Zhong C, Talmage D, Role L. Nicotine elicits prolonged calcium signaling along ventral hippocampal axons. PLoS ONE. 2013;8:e82719 pubmed publisher
Platt N, Gispert S, Auburger G, Cragg S. Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice. PLoS ONE. 2012;7:e36397 pubmed publisher
Caiati M, Sivakumaran S, Lanore F, Mulle C, Richard E, Verrier D, et al. Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses. Sci Rep. 2012;2:285 pubmed publisher
Goddard C, Sridharan D, Huguenard J, Knudsen E. Gamma oscillations are generated locally in an attention-related midbrain network. Neuron. 2012;73:567-80 pubmed publisher
Li Y, LaCroix C, Freeling J. Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors. Auton Neurosci. 2010;154:14-9 pubmed publisher
Li Y, LaCroix C, Freeling J. Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses. Neurosci Lett. 2009;462:20-3 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2349
SKU :
2349/10
product name :
Dihydro-b-erythroidine hydrobromide
description :
4 2, muscle type and Torpedo nAChR antagonist
target :
Additional Nicotinic Receptor Antagonists
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
98%
storage :
Desiccate at RT
observed molecular weight :
356.26
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Dihydro- -erythroidine hydrobromide is a member of the Erythrina alkaloids, it is a competitive nicotinic acetylcholine receptor antagonist with moderate selectivity for the neuronal 4 receptor subunit (IC50 values are 0.19 and 0.37 M for 4 4 and 4 2 receptors, respectively). Antagonizes behavioral effects of nicotine in vivo . Dihydro- -erythroidine blocks excitation of striatal GABAergic neurons, which completely suppress polysynaptic inhibition between striatal cholinergic interneurons. Dihydro- -erythroidine hydrobromide has antidepressive-like effects in mice (forced swim and mouse suspension). Orally bioavailable.
product keywords :
antagonists neuronal alpha4-containing nicotinic receptors 4 2 a4b2 Nicotinic Receptors Acetylcholine nAChR Non-Selective Subtypes Other Dihydro-beta-erythroidine hydrobromide Dihydro- -erythroidine hydrobromide DH E DHbE Nicotinic Receptors (Other Subtypes) Nicotinic (a4b2) Receptors 2349,
extended description :
4 2, muscle type and Torpedo nAChR antagonist
chemical name text :
(2S,13bS)-2-Methoxy-2,3,5,6,8,9,10,13-octahydro-1H,12H-benzo[i]pyrano[3,4-g]indolizin-12-one hydrobromide
formula :
C16H21NO3.HBr
formula text :
C16H21NO3.HBr
cas num :
29734-68-7
USD :
269
USD 2025 :
281 USD
product details :
4 2, muscle type and Torpedo nAChR antagonist
alt names :
DH E
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK