product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Salubrinal
catalog :
2347
quantity :
10 mg
price :
212 USD
more info or order :
citations: 11
Reference
Wang S, Wung C, Chen M, Chen C, Yin P, Yeh T, et al. Activated Integrated Stress Response Induced by Salubrinal Promotes Cisplatin Resistance in Human Gastric Cancer Cells via Enhanced xCT Expression and Glutathione Biosynthesis. Int J Mol Sci. 2018;19: pubmed publisher
Gandin V, Masvidal L, Cargnello M, Gyenis L, McLaughlan S, Cai Y, et al. mTORC1 and CK2 coordinate ternary and eIF4F complex assembly. Nat Commun. 2016;7:11127 pubmed publisher
Hamamura K, Nishimura A, Iino T, Takigawa S, Sudo A, Yokota H. Chondroprotective effects of Salubrinal in a mouse model of osteoarthritis. Bone Joint Res. 2015;4:84-92 pubmed publisher
Vandewynckel Y, Laukens D, Bogaerts E, Paridaens A, Van den Bussche A, Verhelst X, et al. Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy. Hepatol Int. 2015;9:93-104 pubmed publisher
Tran K, Li Y, Duan H, Arora D, Lim H, Wang W. Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death. ACS Chem Biol. 2014;9:2796-806 pubmed publisher
Wan Q, Xu W, Yan J, Yokota H, Na S. Distinctive subcellular inhibition of cytokine-induced SRC by salubrinal and fluid flow. PLoS ONE. 2014;9:e105699 pubmed publisher
Shim J, Hamamura K, Chen A, Wan Q, Na S, Yokota H. Rac1 mediates load-driven attenuation of mRNA expression of nerve growth factor beta in cartilage and chondrocytes. J Musculoskelet Neuronal Interact. 2013;13:372-9 pubmed
Hahn C, Lowrey C. Eukaryotic initiation factor 2? phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism. Blood. 2013;122:477-85 pubmed publisher
Konrad C, Queener S, Wek R, Sullivan W. Inhibitors of eIF2? dephosphorylation slow replication and stabilize latency in Toxoplasma gondii. Antimicrob Agents Chemother. 2013;57:1815-22 pubmed publisher
Bennett H, Fleming J, O Prey J, Ryan K, Leung H. Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cells. Cell Death Dis. 2010;1:e72 pubmed publisher
Bergeron M, Bürzle M, Kovacs G, Simonin A, Hediger M. Synthesis, maturation, and trafficking of human Na+-dicarboxylate cotransporter NaDC1 requires the chaperone activity of cyclophilin B. J Biol Chem. 2011;286:11242-53 pubmed publisher
product information
brand :
Tocris
master code :
2347
SKU :
2347/10
product name :
Salubrinal
description :
Selective inhibitor of eIF2 dephosphorylation
target :
Other ER Stress/UPR Inhibitors
category :
Small Molecules
unit size :
10 mg
purity :
99%
observed molecular weight :
479.81
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit (eIF2 ). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC50 ~ 15 u M).
catalog number base :
2347
product keywords :
Selective inhibitors inhibits eIF2alpha dephosphorylation cellular phosphatases protein synthesis ER stress Protein Ser/Thr Phosphatases Other ER stress/UPR Protein-synthesizing GTPases 2347,
extended description :
Selective inhibitor of eIF2 dephosphorylation
chemical name text :
3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide
formula :
C 21 H 17 N 4 OSCl 3
formula text :
C21H17N4OSCl3
cas num :
405060-95-9
2020 USD :
207
2021 USD :
212 USD
storage :
Store at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK