Salubrinal | Tocris Bioscience 2347/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Salubrinal

catalog :

2347/10

quantity :

10 mg

price :

276 USD

more info or order :

Tocris Bioscience product webpage

citations: 15

Reference
Wang S, Wung C, Chen M, Chen C, Yin P, Yeh T, et al. Activated Integrated Stress Response Induced by Salubrinal Promotes Cisplatin Resistance in Human Gastric Cancer Cells via Enhanced xCT Expression and Glutathione Biosynthesis. Int J Mol Sci. 2018;19: pubmed publisher
Minami K, Liu S, Liu Y, Chen A, Wan Q, Na S, et al. Inhibitory Effects of Dopamine Receptor D1 Agonist on Mammary Tumor and Bone Metastasis. Sci Rep. 2017;7:45686 pubmed publisher
Gandin V, Masvidal L, Cargnello M, Gyenis L, McLaughlan S, Cai Y, et al. mTORC1 and CK2 coordinate ternary and eIF4F complex assembly. Nat Commun. 2016;7:11127 pubmed publisher
Hamamura K, Nishimura A, Iino T, Takigawa S, Sudo A, Yokota H. Chondroprotective effects of Salubrinal in a mouse model of osteoarthritis. Bone Joint Res. 2015;4:84-92 pubmed publisher
Sodhi C, Jia H, Yamaguchi Y, Lu P, Good M, Egan C, et al. Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut. J Immunol. 2015;194:4931-9 pubmed publisher
Vandewynckel Y, Laukens D, Bogaerts E, Paridaens A, Van den Bussche A, Verhelst X, et al. Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy. Hepatol Int. 2015;9:93-104 pubmed publisher
Tran K, Li Y, Duan H, Arora D, Lim H, Wang W. Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death. ACS Chem Biol. 2014;9:2796-806 pubmed publisher
Wan Q, Xu W, Yan J, Yokota H, Na S. Distinctive subcellular inhibition of cytokine-induced SRC by salubrinal and fluid flow. PLoS ONE. 2014;9:e105699 pubmed publisher
Shim J, Hamamura K, Chen A, Wan Q, Na S, Yokota H. Rac1 mediates load-driven attenuation of mRNA expression of nerve growth factor beta in cartilage and chondrocytes. J Musculoskelet Neuronal Interact. 2013;13:372-9 pubmed
Hahn C, Lowrey C. Eukaryotic initiation factor 2? phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism. Blood. 2013;122:477-85 pubmed publisher
Gu L, Johno H, Nakajima S, Kato H, Takahashi S, Katoh R, et al. Blockade of Smad signaling by 3'-deoxyadenosine: a mechanism for its anti-fibrotic potential. Lab Invest. 2013;93:450-61 pubmed publisher
Konrad C, Queener S, Wek R, Sullivan W. Inhibitors of eIF2? dephosphorylation slow replication and stabilize latency in Toxoplasma gondii. Antimicrob Agents Chemother. 2013;57:1815-22 pubmed publisher
Shrestha N, Bahnan W, Wiley D, Barber G, Fields K, Schesser K. Eukaryotic initiation factor 2 (eIF2) signaling regulates proinflammatory cytokine expression and bacterial invasion. J Biol Chem. 2012;287:28738-44 pubmed publisher
Bennett H, Fleming J, O Prey J, Ryan K, Leung H. Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cells. Cell Death Dis. 2010;1:e72 pubmed publisher
Bergeron M, Bürzle M, Kovacs G, Simonin A, Hediger M. Synthesis, maturation, and trafficking of human Na+-dicarboxylate cotransporter NaDC1 requires the chaperone activity of cyclophilin B. J Biol Chem. 2011;286:11242-53 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2347

SKU :

2347/10

product name :

Salubrinal

description :

Selective inhibitor of eIF2 dephosphorylation

target :

Other ER Stress/UPR Inhibitors

unit size :

10 mg

category :

Small Molecules

purity :

99%

storage :

Store at +4°C

observed molecular weight :

479.81

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Salubrinal is a cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit (eIF2 ). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC50 ~ 15 u M).

product keywords :

Selective inhibitors inhibits eIF2alpha dephosphorylation cellular phosphatases protein synthesis ER stress Protein Ser/Thr Phosphatases Other ER stress/UPR Protein-synthesizing GTPases 2347,

extended description :

Selective inhibitor of eIF2 dephosphorylation

chemical name text :

3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide

formula :

C21H17N4OSCl3

formula text :

C21H17N4OSCl3

cas num :

405060-95-9

USD :

264

USD 2025 :

276 USD

product details :

Selective inhibitor of eIF2 dephosphorylation

more info or order :

Tocris Bioscience product webpage