ZK 200775 | Tocris Bioscience 2345 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ZK 200775

catalog :

2345

quantity :

10 mg (also 50 mg)

price :

223 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Lesne S, Gabriel C, Nelson D, White E, Mackenzie E, Vivien D, et al. Akt-dependent expression of NAIP-1 protects neurons against amyloid-{beta} toxicity. J Biol Chem. 2005;280:24941-7 pubmed

product information

brand :

Tocris

master code :

2345

SKU :

2345/10

product name :

ZK 200775

description :

Competitive non-NMDA iGluR antagonist

target :

AMPA Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

409.25

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Competitive AMPA/kainate antagonist. In rat cortical membranes, displays high affinity for [3H]-AMPA (Ki = 120 nM) and [3H]-CNQX (Ki = 32 nM) binding sites and low affinity for kainate and NMDA channel-associated binding sites (IC50 values range from 2.5 to 11 u M). Inhibits currents induced by AMPA, kainate and NMDA with IC50 values of 21 nM, 27 nM, and 1 u M respectively. Displays anxiolytic, anticonvulsant and muscle relaxant activity in vivo .

catalog number base :

2345

product keywords :

Competitive AMPA/kainate antagonists Glutamate Receptors iGluR Ionotropic ZK200775 MPQX AMPA Receptors Kainate Receptors 2345,

extended description :

Competitive non-NMDA iGluR antagonist

chemical name text :

[[3,4-Dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]phosphonic acid

formula :

C 14 H 15 N 3 O 6 F 3 P

formula text :

C14H15N3O6F3P

cas num :

161605-73-8

2020 USD :

216

2021 USD :

223 USD

alt names :

MPQX

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage