product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
WEB 2086
catalog :
2339
quantity :
1 mg (also 10 mg)
price :
127 USD
more info or order :
citations: 6
Reference
Yagnik D. Macrophage derived platelet activating factor implicated in the resolution phase of gouty inflammation. Int J Inflam. 2014;2014:526496 pubmed publisher
Gabl M, Winther M, Skovbakke S, Bylund J, Dahlgren C, Forsman H. A pepducin derived from the third intracellular loop of FPR2 is a partial agonist for direct activation of this receptor in neutrophils but a full agonist for cross-talk triggered reactivation of FPR2. PLoS ONE. 2014;9:e109516 pubmed publisher
Wu H, Yang J, Su E, Li L, Zhao C, Yang X, et al. Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. PLoS ONE. 2014;9:e93003 pubmed publisher
Zhao C, Su E, Yang X, Gao Z, Li L, Wu H, et al. Important role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice. PLoS ONE. 2013;8:e82683 pubmed publisher
Ajiro Y, Saegusa N, Giles W, Stafforini D, Spitzer K. Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes. Am J Physiol Heart Circ Physiol. 2011;301:H2395-401 pubmed publisher
Al Shawaf E, Naylor J, Taylor H, Riches K, Milligan C, O Regan D, et al. Short-term stimulation of calcium-permeable transient receptor potential canonical 5-containing channels by oxidized phospholipids. Arterioscler Thromb Vasc Biol. 2010;30:1453-9 pubmed publisher
product information
brand :
Tocris
master code :
2339
SKU :
2339/1
product name :
WEB 2086
description :
Potent PAF receptor antagonist
target :
Platelet-activating Factor Receptor Antagonists
category :
Small Molecules
unit size :
1 mg (also 10 mg)
purity :
99%
observed molecular weight :
455.96
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Potent, selective platelet-activating factor (PAF) receptor antagonist (Ki = 16.3 nM). Displays anti-inflammatory, antiangiogenic and anticancer activity. Inhibits growth and proliferation of MCF-7 breast cancer cells.
catalog number base :
2339
product keywords :
Potent PAF receptor antagonists Receptors Platelet-activating Factor WEB2086 Apafant Platelet-activating Factor (PAF) Receptors 2339,
extended description :
Potent PAF receptor antagonist
chemical name text :
4-[3-[4[(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a]diazepin-2-yl]-1-oxopropyl]morpholine
formula :
C 22 H 22 N 5 O 2 SCl
formula text :
C22H22N5O2SCl
cas num :
105219-56-5
2020 USD :
123
2021 USD :
127 USD
alt names :
Apafant
storage :
Desiccate at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK