MK 571 | Tocris Bioscience 2338/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

MK 571

catalog :

2338/10

quantity :

10 mg

price :

251 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Wright P, McCoull D, Walsh Y, Large J, Hadrys B, Gaurilcikaite E, et al. Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2. Biochem Biophys Res Commun. 2019;520:35-40 pubmed publisher
Schnúr A, Premchandar A, Bagdany M, Lukacs G. Phosphorylation-dependent modulation of CFTR macromolecular signalling complex activity by cigarette smoke condensate in airway epithelia. Sci Rep. 2019;9:12706 pubmed publisher
Rees M, Seashore Ludlow B, Cheah J, Adams D, Price E, Gill S, et al. Correlating chemical sensitivity and basal gene expression reveals mechanism of action. Nat Chem Biol. 2016;12:109-16 pubmed publisher
Hoque M, Kis O, De Rosa M, Bendayan R. Raltegravir permeability across blood-tissue barriers and the potential role of drug efflux transporters. Antimicrob Agents Chemother. 2015;59:2572-82 pubmed publisher
Stott L, Schnell S, Hogstrand C, Owen S, Bury N. A primary fish gill cell culture model to assess pharmaceutical uptake and efflux: evidence for passive and facilitated transport. Aquat Toxicol. 2015;159:127-37 pubmed publisher
Hill C, Jamieson D, Thomas H, Brown C, Boddy A, Veal G. Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo. Biochem Pharmacol. 2013;85:29-37 pubmed publisher

product information

brand :

Tocris

catalog number base :

2338

SKU :

2338/10

product name :

MK 571

units size :

10 mg

description :

Potent CysLT1 (LTD4) inverse agonist. Also MRP1 inhibitor

target :

Leukotriene and Related Receptor Inverse Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

515.09

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

MK 571 is a potent CysLT1 (LTD4) leukotriene receptor inverse agonist (EC50 = 1.3 nM). Antagonizes LTD4-induced contractions of guinea pig trachea and ileum (pA2 values are 9.4 and 10.5 respectively). Also inhibitor of multidrug resistance protein-1 (MRP1) mediated transport; in vitro augments the effects of cytotoxic agents on malignant cells.

top caption :

Potent CysLT1 (LTD4) inverse agonist. Also MRP1 inhibitor

extended description :

Potent CysLT1 (LTD4) inverse agonist. Also MRP1 inhibitor

chemical name text :

3-[[[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propanoic acid

formula :

C26H27ClN2O3S2

formula text :

C26H27ClN2O3S2

cas num :

115104-28-4

USD :

251 USD

product details :

Potent CysLT1 (LTD4) inverse agonist. Also MRP1 inhibitor

alt names :

L-660711

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage