Trequinsin hydrochloride | Tocris Bioscience 2337 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Trequinsin hydrochloride

catalog :

2337

quantity :

10 mg

price :

295 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
McBrinn R, Fraser J, Hope A, Gray D, Barratt C, Martins da Silva S, et al. Novel pharmacological actions of Trequinsin Hydrochloride improve human sperm cell motility and function. Br J Pharmacol. 2019;: pubmed publisher

product information

brand :

Tocris

master code :

2337

SKU :

2337/10

product name :

Trequinsin hydrochloride

description :

Highly potent PDE3 inhibitor

target :

Phosphodiesterase Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

97%

observed molecular weight :

441.95

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Highly potent inhibitor of cGMP-inhibited phosphodiesterase (PDE3; IC50 = 250 pM). Potently inhibits arachidonic acid-induced aggregation of human platelets (IC50 = 50 pM). Orally active antihypertensive agent; reduces systemic blood pressure in both normotensive and hypertensive animal models. Also activates CatSper channels, increases intracellular Ca2+ and cGMP levels, and decreases potassium channel activity in sperm.

catalog number base :

2337

product keywords :

Ultrapotent inhibitors inhibits PDE3 Phosphodiesterases HL725 Catsper activators activates sperm motility HL-725 Phosphodiesterases Other Calcium Channels 2337,

extended description :

Highly potent PDE3 inhibitor

chemical name text :

2,3,6,7-Tetrahydro-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-4H-pyrimido[6,1-a]isoquinolin-4-one hydrochloride

formula :

C 24 H 27 N 3 O 3 .HCl

formula text :

C24H27N3O3.HCl

cas num :

78416-81-6

2020 USD :

286

2021 USD :

295 USD

alt names :

HL-725

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage