Trequinsin hydrochloride | Tocris Bioscience 2337/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Trequinsin hydrochloride

catalog :

2337/10

quantity :

10 mg

price :

370 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
McBrinn R, Fraser J, Hope A, Gray D, Barratt C, Martins da Silva S, et al. Novel pharmacological actions of Trequinsin Hydrochloride improve human sperm cell motility and function. Br J Pharmacol. 2019;: pubmed publisher

product information

brand :

Tocris

catalog number base :

2337

SKU :

2337/10

product name :

Trequinsin hydrochloride

units size :

10 mg

description :

Highly potent PDE3 inhibitor

target :

Phosphodiesterase Inhibitors

category :

Small Molecules

purity :

97%

observed molecular weight :

441.95

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Trequinsin hydrochloride is a highly potent inhibitor of cGMP-inhibited phosphodiesterase (PDE3; IC50 = 250 pM). Potently inhibits arachidonic acid-induced aggregation of human platelets (IC50 = 50 pM). Orally active antihypertensive agent; reduces systemic blood pressure in both normotensive and hypertensive animal models. Also activates CatSper channels, increases intracellular Ca2+ and cGMP levels, and decreases potassium channel activity in sperm.

top caption :

Highly potent PDE3 inhibitor

extended description :

Highly potent PDE3 inhibitor

chemical name text :

2,3,6,7-Tetrahydro-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-4H-pyrimido[6,1-a]isoquinolin-4-one hydrochloride

formula :

C24H27N3O3.HCl

formula text :

C24H27N3O3.HCl

cas num :

78416-81-6

USD :

370 USD

product details :

Highly potent PDE3 inhibitor

alt names :

HL-725

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage