JNJ 16259685 | Tocris Bioscience 2333/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

JNJ 16259685

catalog :

2333/10

quantity :

10 mg (also 50 mg)

price :

333 USD

more info or order :

Tocris Bioscience product webpage

citations: 12

Reference
O Riordan K, Hu N, Rowan M. Physiological activation of mGlu5 receptors supports the ion channel function of NMDA receptors in hippocampal LTD induction in vivo. Sci Rep. 2018;8:4391 pubmed publisher
Rizwan A, Zhan X, Zamponi G, Turner R. Long-Term Potentiation at the Mossy Fiber-Granule Cell Relay Invokes Postsynaptic Second-Messenger Regulation of Kv4 Channels. J Neurosci. 2016;36:11196-11207 pubmed
Johansson F, Carlsson H, Rasmussen A, Yeo C, Hesslow G. Activation of a Temporal Memory in Purkinje Cells by the mGluR7 Receptor. Cell Rep. 2015;13:1741-6 pubmed publisher
Tabatadze N, Huang G, May R, Jain A, Woolley C. Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus. J Neurosci. 2015;35:11252-65 pubmed publisher
Lum E, Campbell R, Rostock C, Szumlinski K. mGluR1 within the nucleus accumbens regulates alcohol intake in mice under limited-access conditions. Neuropharmacology. 2014;79:679-87 pubmed publisher
Loweth J, Scheyer A, Milovanovic M, Lacrosse A, Flores Barrera E, Werner C, et al. Synaptic depression via mGluR1 positive allosteric modulation suppresses cue-induced cocaine craving. Nat Neurosci. 2014;17:73-80 pubmed publisher
Jensen R. Effects of a metabotropic glutamate 1 receptor antagonist on light responses of retinal ganglion cells in a rat model of retinitis pigmentosa. PLoS ONE. 2013;8:e79126 pubmed publisher
He L, Linden D, Sapirstein A. Astrocyte inositol triphosphate receptor type 2 and cytosolic phospholipase A2 alpha regulate arteriole responses in mouse neocortical brain slices. PLoS ONE. 2012;7:e42194 pubmed publisher
Zheng N, Raman I. Prolonged postinhibitory rebound firing in the cerebellar nuclei mediated by group I metabotropic glutamate receptor potentiation of L-type calcium currents. J Neurosci. 2011;31:10283-92 pubmed publisher
Hildebrand M, Isope P, Miyazaki T, Nakaya T, Garcia E, Feltz A, et al. Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines. J Neurosci. 2009;29:9668-82 pubmed publisher
Shin J, Kim Y, Linden D. Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells. Proc Natl Acad Sci U S A. 2008;105:746-50 pubmed publisher
Fukunaga I, Yeo C, Batchelor A. Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices. Br J Pharmacol. 2007;151:870-6 pubmed

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2333

SKU :

2333/10

product name :

JNJ 16259685

description :

Highly potent, mGlu1-selective non-competitive antagonist

target :

Group I mGluR Antagonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

325.41

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

JNJ 16259685 is a sub-nanomolar potent, non-competitive mGlu1 antagonist (Ki = 0.34 nM). Inhibits glutamate-induced Ca2+ response at the human mGlu1 receptor with an IC50 value of 0.55 nM. Selective over mGlu5 ( 400-fold) and displays no activity at mGlu2, mGlu3, mGlu4, mGlu6, AMPA or NMDA receptors (IC50 10 u M). Centrally active following systemic administration.

product keywords :

potent mGlu1 mGluR1-selective non-competitive antagonists Group I Receptors Glutamate Metabotropic JNJ16259685 Glutamate (Metabotropic) Group I Receptors 2333,

extended description :

Highly potent, mGlu1-selective non-competitive antagonist

chemical name text :

(3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone

formula :

C20H23NO3

formula text :

C20H23NO3

cas num :

409345-29-5

USD :

323

USD 2025 :

333 USD

product details :

Highly potent, mGlu1-selective non-competitive antagonist

more info or order :

Tocris Bioscience product webpage