Necrostatin-1 | Tocris Bioscience 2324 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Necrostatin-1

catalog :

2324

quantity :

10 mg (also 50 mg)

price :

125 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Chefetz I, Grimley E, Yang K, Hong L, Vinogradova E, Suciu R, et al. A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. Cell Rep. 2019;26:3061-3075.e6 pubmed publisher
Greer Y, Porat Shliom N, Nagashima K, Stuelten C, Crooks D, Koparde V, et al. ONC201 kills breast cancer cells in vitro by targeting mitochondria. Oncotarget. 2018;9:18454-18479 pubmed publisher
Kim H, Hwang K, Park D, Oh S, Jun H, Yoon K, et al. Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells. J Transl Med. 2017;15:123 pubmed publisher
Sagher E, Hernandez L, Heywood C, Pauly G, Young M, Schneider J, et al. The small molecule NSC676914A is cytotoxic and differentially affects NFÎºB signaling in ovarian cancer cells and HEK293 cells. Cancer Cell Int. 2014;14:75 pubmed publisher

product information

brand :

Tocris

master code :

2324

SKU :

2324/10

product name :

Necrostatin-1

description :

RIP1 kinase inhibitor; inhibits necroptosis

target :

RIP Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

259.33

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis (EC50 = 494 nM). Reduces ischemic brain injury in a mouse model of stroke.

catalog number base :

2324

product keywords :

non-apoptotic cell death necroptosis Death domain receptor-associated adaptor RIP1 inhibits inhibitors Apoptosis RIPK RIPK1 receptor-interacting protein kinase 1 other kinases Necroptosis RIP Kinases 2324, RIP 1, RIP Kinase, RIPK1, inihibitor

extended description :

RIP1 kinase inhibitor; inhibits necroptosis

chemical name text :

5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone

formula :

C 13 H 13 N 3 OS

formula text :

C13H13N3OS

cas num :

4311-88-0

2020 USD :

120

2021 USD :

125 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage