Necrostatin-1 | Tocris Bioscience 2324/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Necrostatin-1

catalog :

2324/10

quantity :

10 mg (also 50 mg)

price :

159 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Chefetz I, Grimley E, Yang K, Hong L, Vinogradova E, Suciu R, et al. A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. Cell Rep. 2019;26:3061-3075.e6 pubmed publisher
Thibault B, Genre L, Le Naour A, Broca C, Mery E, Vuagniaux G, et al. DEBIO 1143, an IAP inhibitor, reverses carboplatin resistance in ovarian cancer cells and triggers apoptotic or necroptotic cell death. Sci Rep. 2018;8:17862 pubmed publisher
Greer Y, Porat Shliom N, Nagashima K, Stuelten C, Crooks D, Koparde V, et al. ONC201 kills breast cancer cells in vitro by targeting mitochondria. Oncotarget. 2018;9:18454-18479 pubmed publisher
LÃ¶tzerich M, Roulin P, Boucke K, Witte R, Georgiev O, Greber U. Rhinovirus 3C protease suppresses apoptosis and triggers caspase-independent cell death. Cell Death Dis. 2018;9:272 pubmed publisher
Alvarez S, Sviderskiy V, Terzi E, Papagiannakopoulos T, Moreira A, Adams S, et al. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis. Nature. 2017;551:639-643 pubmed publisher
Kim H, Hwang K, Park D, Oh S, Jun H, Yoon K, et al. Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells. J Transl Med. 2017;15:123 pubmed publisher
Sagher E, Hernandez L, Heywood C, Pauly G, Young M, Schneider J, et al. The small molecule NSC676914A is cytotoxic and differentially affects NFÎºB signaling in ovarian cancer cells and HEK293 cells. Cancer Cell Int. 2014;14:75 pubmed publisher
Zhao C, Pavicic P, Datta S, Sun D, Novotny M, Hamilton T. Cellular stress amplifies TLR3/4-induced CXCL1/2 gene transcription in mononuclear phagocytes via RIPK1. J Immunol. 2014;193:879-88 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2324

SKU :

2324/10

product name :

Necrostatin-1

description :

RIP1 kinase inhibitor; inhibits necroptosis

target :

RIP Kinase Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at RT

observed molecular weight :

259.33

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Necrostatin-1 is an ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis (EC50 = 494 nM). Reduces ischemic brain injury in a mouse model of stroke.

product keywords :

non-apoptotic cell death necroptosis Death domain receptor-associated adaptor RIP1 inhibits inhibitors Apoptosis RIPK RIPK1 receptor-interacting protein kinase 1 other kinases Necroptosis RIP Kinases 2324, RIP 1, RIP Kinase, RIPK1, inihibitor

extended description :

RIP1 kinase inhibitor; inhibits necroptosis

chemical name text :

5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone

formula :

C13H13N3OS

formula text :

C13H13N3OS

cas num :

4311-88-0

USD :

157

USD 2025 :

159 USD

product details :

RIP1 kinase inhibitor; inhibits necroptosis

more info or order :

Tocris Bioscience product webpage