AMG 9810 | Tocris Bioscience 2316/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AMG 9810

catalog :

2316/10

quantity :

10 mg (also 50 mg)

price :

208 USD

more info or order :

Tocris Bioscience product webpage

citations: 17

Reference
Chen C, Chang C, Hsu Y, Peng Y, Lee H, Huang G. fMRI indicates cortical activation through TRPV1 modulation during acute gouty attacks. Sci Rep. 2019;9:12348 pubmed publisher
Pearce L, Ann J, Blumberg P, Lee J. Combination of a Rapidly Penetrating Agonist and a Slowly Penetrating Antagonist Affords Agonist Action of Limited Duration at the Cellular Level. Biomol Ther (Seoul). 2019;27:435-441 pubmed publisher
Mouchbahani Constance S, Lesperance L, Petitjean H, Davidova A, MacPherson A, Prescott S, et al. Lionfish venom elicits pain predominantly through the activation of nonpeptidergic nociceptors. Pain. 2018;159:2255-2266 pubmed publisher
Jeong J, Lee D, Liu S, Chua S, Schwartz G, Jo Y. Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake. PLoS Biol. 2018;16:e2004399 pubmed publisher
David Pereira A, Sagalajev B, Wei H, Almeida A, Pertovaara A, Pinto Ribeiro F. The medullary dorsal reticular nucleus as a relay for descending pronociception induced by the mGluR5 in the rat infralimbic cortex. Neuroscience. 2017;349:341-354 pubmed publisher
Martin H, Bernabeu A, Lassalle O, Bouille C, Beurrier C, Pelissier Alicot A, et al. Endocannabinoids Mediate Muscarinic Acetylcholine Receptor-Dependent Long-Term Depression in the Adult Medial Prefrontal Cortex. Front Cell Neurosci. 2015;9:457 pubmed publisher
Li Y, Adamek P, Zhang H, Tatsui C, Rhines L, Mrozkova P, et al. The Cancer Chemotherapeutic Paclitaxel Increases Human and Rodent Sensory Neuron Responses to TRPV1 by Activation of TLR4. J Neurosci. 2015;35:13487-500 pubmed publisher
Wang C, Sun D, Liu C, Zhu C, Jing X, Chen S, et al. Mother root of Aconitum carmichaelii Debeaux exerts antinociceptive effect in Complet Freund's Adjuvant-induced mice: roles of dynorpin/kappa-opioid system and transient receptor potential vanilloid type-1 ion channel. J Transl Med. 2015;13:284 pubmed publisher
Montrucchio D, Córdova M, Santos A. Plant derived aporphinic alkaloid S-(+)-dicentrine induces antinociceptive effect in both acute and chronic inflammatory pain models: evidence for a role of TRPA1 channels. PLoS ONE. 2013;8:e67730 pubmed publisher
Hakimizadeh E, Oryan S, Hajizadeh Moghaddam A, Shamsizadeh A, Roohbakhsh A. Endocannabinoid System and TRPV1 Receptors in the Dorsal Hippocampus of the Rats Modulate Anxiety-like Behaviors. Iran J Basic Med Sci. 2012;15:795-802 pubmed
Saloman J, Chung M, Ro J. P2X? and TRPV1 functionally interact and mediate sensitization of trigeminal sensory neurons. Neuroscience. 2013;232:226-38 pubmed publisher
Sisignano M, Park C, Angioni C, Zhang D, von Hehn C, Cobos E, et al. 5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals. J Neurosci. 2012;32:6364-72 pubmed publisher
Gregus A, Doolen S, Dumlao D, Buczynski M, Takasusuki T, Fitzsimmons B, et al. Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors. Proc Natl Acad Sci U S A. 2012;109:6721-6 pubmed publisher
Park C, Xu Z, Liu T, Lu N, Serhan C, Ji R. Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1. J Neurosci. 2011;31:18433-8 pubmed publisher
Yan J, Edelmayer R, Wei X, De Felice M, Porreca F, Dussor G. Dural afferents express acid-sensing ion channels: a role for decreased meningeal pH in migraine headache. Pain. 2011;152:106-13 pubmed publisher
Patwardhan A, Scotland P, Akopian A, Hargreaves K. Activation of TRPV1 in the spinal cord by oxidized linoleic acid metabolites contributes to inflammatory hyperalgesia. Proc Natl Acad Sci U S A. 2009;106:18820-4 pubmed publisher
Pitcher M, Price T, Entrena J, Cervero F. Spinal NKCC1 blockade inhibits TRPV1-dependent referred allodynia. Mol Pain. 2007;3:17 pubmed

image

image 1 :

Cat.No. 2316 - AMG 9810 C21H23NO3 CAS No. 545395-94-6

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

2316

SKU :

2316/10

product name :

AMG 9810

Description :

Potent and selective TRPV1 competitive antagonist

target :

TRPV Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

337.42

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AMG 9810 is a potent and selective, competitive vanilloid TRPV1 receptor antagonist (IC50 = 17 nM). Inhibits capsaicin-, proton-, heat- and endogenous ligand-induced activation of human and rat recombinant TRPV1 receptors. Displays antihyperalgesic properties in a rat model of inflammatory pain.

extended description :

Potent and selective TRPV1 competitive antagonist

chemical name text :

(2E)-N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-propenamide

formula :

C 21 H 23 NO 3

formula text :

C21H23NO3

cas num :

545395-94-6

USD :

208 USD

product details :

Potent and selective TRPV1 competitive antagonist

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage