product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
QX 314 chloride
catalog :
2313
quantity :
50 mg
price :
139 USD
more info or order :
citations: 9
Reference
Birdsong W, Jongbloets B, Engeln K, Wang D, Scherrer G, Mao T. Synapse-specific opioid modulation of thalamo-cortico-striatal circuits. elife. 2019;8: pubmed publisher
Arvin M, Wokosin D, Banala S, Lavis L, Drenan R. Probing Nicotinic Acetylcholine Receptor Function in Mouse Brain Slices via Laser Flash Photolysis of Photoactivatable Nicotine. J Vis Exp. 2019;: pubmed publisher
Dong W, Radulović T, Goral R, Thomas C, Suarez Montesinos M, Guerrero Given D, et al. CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse. Cell Rep. 2018;24:284-293.e6 pubmed publisher
Collins D, Anastasiades P, Marlin J, Carter A. Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei. Neuron. 2018;98:366-379.e4 pubmed publisher
Hull C. Measuring Feedforward Inhibition and Its Impact on Local Circuit Function. Cold Spring Harb Protoc. 2017;2017: pubmed publisher
Bell L, Bell K, McQuiston A. Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation. Front Cell Neurosci. 2015;9:115 pubmed publisher
Cunningham M, Cho J, Leung A, Savvidis G, Ahn S, Moon M, et al. hPSC-derived maturing GABAergic interneurons ameliorate seizures and abnormal behavior in epileptic mice. Cell Stem Cell. 2014;15:559-73 pubmed publisher
Wood L, Gray N, Zhou Z, Greenberg M, Shepherd G. Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in an RNA interference model of methyl-CpG-binding protein 2 deficiency. J Neurosci. 2009;29:12440-8 pubmed publisher
Wang Z, Kai L, Day M, Ronesi J, Yin H, Ding J, et al. Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons. Neuron. 2006;50:443-52 pubmed
product information
brand :
Tocris
master code :
2313
SKU :
2313/50
product name :
QX 314 chloride
description :
Na+ channel blocker
target :
Voltage-gated Sodium Channel Blockers
category :
Small Molecules
unit size :
50 mg
purity :
99%
observed molecular weight :
298.85
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels.
catalog number base :
2313
product keywords :
Na+ channel blockers Sodium NaV Channels voltage-gated voltage-dependent QX314 chloride Voltage-gated Sodium Channels 2313,
extended description :
Na+ channel blocker
chemical name text :
N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride
formula :
C 16 H 27 N 2 OCl
formula text :
C16H27N2OCl
cas num :
3/9/69
2020 USD :
132
2021 USD :
139 USD
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK