L-168,049 | Tocris Bioscience 2311 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

L-168,049

catalog :

2311

quantity :

10 mg (also 50 mg)

price :

184 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Rodriguez Diaz R, Molano R, Weitz J, Abdulreda M, Berman D, Leibiger B, et al. Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point. Cell Metab. 2018;27:549-558.e4 pubmed publisher

product information

brand :

Tocris

master code :

2311

SKU :

2311/10

product name :

L-168,049

description :

Potent, orally active human glucagon receptor antagonist

target :

Glucagon Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

467.79

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Very potent and selective, non-competitive antagonist of the human glucagon receptor (hGR). Binds with high affinity to human GR (IC50 = 3.7 nM), and moderate affinity to murine and canine GRs (IC50 values are 63 and 60 nM respectively). In contrast, displays poor affinity for rat, guinea pig, and rabbit glucagon receptors (IC50 1 u M). In functional studies, inhibits glucagon-stimulated cAMP synthesis in CHO cells expressing hGR (IC50 = 41 nM), and in murine liver membranes. Orally active in vivo .

catalog number base :

2311

product keywords :

Potent orally active human glucagon receptor antagonists Receptors L168049 Glucagon Receptor 2311,

extended description :

Potent, orally active human glucagon receptor antagonist

chemical name text :

4-[3-(5-Bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]pyridine

formula :

C 24 H 20 BrClN 2 O

formula text :

C24H20BrClN2O

cas num :

191034-25-0

2020 USD :

176

2021 USD :

184 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage