SR 49059 | Tocris Bioscience 2310 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SR 49059

catalog :

2310

quantity :

10 mg

price :

363 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Xiao L, Priest M, Kozorovitskiy Y. Oxytocin functions as a spatiotemporal filter for excitatory synaptic inputs to VTA dopamine neurons. elife. 2018;7: pubmed publisher
Xiao L, Priest M, Nasenbeny J, Lu T, Kozorovitskiy Y. Biased Oxytocinergic Modulation of Midbrain Dopamine Systems. Neuron. 2017;95:368-384.e5 pubmed publisher
Faraco G, Wijasa T, Park L, Moore J, Anrather J, Iadecola C. Water deprivation induces neurovascular and cognitive dysfunction through vasopressin-induced oxidative stress. J Cereb Blood Flow Metab. 2014;34:852-60 pubmed publisher
Zhu W, Tilley D, Myers V, Coleman R, Feldman A. Arginine vasopressin enhances cell survival via a G protein-coupled receptor kinase 2/?-arrestin1/extracellular-regulated kinase 1/2-dependent pathway in H9c2 cells. Mol Pharmacol. 2013;84:227-35 pubmed publisher
Manaenko A, Fathali N, Khatibi N, Lekic T, Shum K, Martin R, et al. Post-treatment with SR49059 improves outcomes following an intracerebral hemorrhagic stroke in mice. Acta Neurochir Suppl. 2011;111:191-6 pubmed publisher
Manaenko A, Fathali N, Khatibi N, Lekic T, Hasegawa Y, Martin R, et al. Arginine-vasopressin V1a receptor inhibition improves neurologic outcomes following an intracerebral hemorrhagic brain injury. Neurochem Int. 2011;58:542-8 pubmed publisher

product information

brand :

Tocris

master code :

2310

SKU :

2310/10

product name :

SR 49059

description :

Selective, orally active vasopressin V1A receptor antagonist

target :

Vasopressin Receptor Antagonists

category :

Small Molecules

unit size :

10 mg

purity :

99%

observed molecular weight :

620.5

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective non-peptide vasopressin V1A receptor antagonist; devoid of agonist activity. Displays high affinity and efficacy at both rat (Ki = 1.6 nM) and human (Ki = 1.1 - 6.3 nM) V1A receptors. Potently antagonizes arginine vasopressin-induced effects in vitro (IC50 = 3.7 nM for inhibition of human platelet aggregation) and is orally active in vivo .

catalog number base :

2310

product keywords :

Selective orally active vasopressin V1a receptor antagonists V2 Receptors SR49059 Relcovaptan Vasopressin Receptors 2310,

extended description :

Selective, orally active vasopressin V1A receptor antagonist

chemical name text :

(2S)-1-[[(2R,3S)-5-Chloro-3-(2-chlorophenyl)-1-[(3,4-dimethoxyphenyl)sulfonyl]-2,3-dihydro-3-hydroxy-1H-indol-2-yl]carbonyl]-2-pyrrolidinecarboxamide

formula :

C 28 H 27 Cl 2 N 3 O 7 S

formula text :

C28H27Cl2N3O7S

cas num :

150375-75-0

2020 USD :

349

2021 USD :

363 USD

alt names :

Relcovaptan

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage