SR 142948 | Tocris Bioscience 2309/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SR 142948

catalog :

2309/1

quantity :

1 mg (also 10 mg)

price :

182 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Rouibi K, Bose P, RomprÃ© P, Warren R. Ventral Midbrain NTS1 Receptors Mediate Conditioned Reward Induced by the Neurotensin Analog, D-Tyr[11]neurotensin. Front Neurosci. 2015;9:470 pubmed publisher
Piccart E, Courtney N, Branch S, Ford C, Beckstead M. Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons. J Neurosci. 2015;35:11144-52 pubmed publisher
Olszewski Hamilton U, Hamilton G. Dependence of Relative Expression of NTR1 and EGFR on Cell Density and Extracellular pH in Human Pancreatic Cancer Cell Lines. Cancers (Basel). 2011;3:182-97 pubmed publisher
Yin H, Adermark L, Lovinger D. Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling. Neuropharmacology. 2008;54:79-86 pubmed

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2309

SKU :

2309/1

product name :

SR 142948

description :

Highly potent NTS receptor antagonist

target :

Neurotensin Receptor Antagonists

unit size :

1 mg (also 10 mg)

category :

Small Molecules

purity :

97%

storage :

Store at +4°C

observed molecular weight :

685.86

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SR 142948 is a potent non-peptide neurotensin (NT) receptor antagonist that binds with high affinity (IC50 = 0.32 - 3.96 nM; Ki 10 nM). Attenuates amphetamine-induced hyperactivity and is orally active in vivo .

product keywords :

potent NT receptor antagonists Receptors Neurotensin SR142948 Neurotensin Receptors 2309,

extended description :

Highly potent NTS receptor antagonist

chemical name text :

2-[[[5-(2,6-Dimethoxyphenyl)-1-[4-[[[3-(dimethylamino)propyl]methylamino]carbonyl]-2-(1-methylethyl)phenyl]-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[3.3.1.13,7]decane-2-carboxylic acid

formula :

C39H51N5O6

formula text :

C39H51N5O6

cas num :

184162-64-9

USD :

176

USD 2025 :

182 USD

product details :

Highly potent NTS receptor antagonist

more info or order :

Tocris Bioscience product webpage