Tautomycetin | Tocris Bioscience 2305/50U product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Tautomycetin

catalog :

2305/50U

quantity :

50 ug

price :

405 USD

citations: 17

Reference
Garzón J, Ursich S, Lopes M, Hiraga S, Donaldson A. Human RIF1-Protein Phosphatase 1 Prevents Degradation and Breakage of Nascent DNA on Replication Stalling. Cell Rep. 2019;27:2558-2566.e4 pubmed publisher
Messal H, Alt S, Ferreira R, Gribben C, Wang V, Cotoi C, et al. Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis. Nature. 2019;566:126-130 pubmed publisher
Pyo K, Kim C, Lee M, Kim J, Kim K, Baek S. ULK1 O-GlcNAcylation Is Crucial for Activating VPS34 via ATG14L during Autophagy Initiation. Cell Rep. 2018;25:2878-2890.e4 pubmed publisher
Wan L, Ren L, Chen L, Wang G, Liu X, Wang B, et al. M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation. Front Mol Neurosci. 2018;11:287 pubmed publisher
Georgilis A, Klotz S, Hanley C, Herranz N, Weirich B, Morancho B, et al. PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells. Cancer Cell. 2018;34:85-102.e9 pubmed publisher
Liu J, Sharma K, Zangrandi L, Chen C, Humphrey S, Chiu Y, et al. In vivo brain GPCR signaling elucidated by phosphoproteomics. Science. 2018;360: pubmed publisher
Alver R, Chadha G, Gillespie P, Blow J. Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1. Cell Rep. 2017;18:2508-2520 pubmed publisher
Hiraga S, Ly T, Garzón J, Horejsi Z, Ohkubo Y, Endo A, et al. Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation. EMBO Rep. 2017;18:403-419 pubmed publisher
Engmann O, Giralt A, Gervasi N, Marion Poll L, Gasmi L, Filhol O, et al. DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons. Nat Commun. 2015;6:10099 pubmed publisher
Mirante O, Brandalise F, Bohacek J, Mansuy I. Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala. Front Mol Neurosci. 2014;7:62 pubmed publisher
Hegarat N, Vesely C, Vinod P, Ocasio C, Peter N, Gannon J, et al. PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit. PLoS Genet. 2014;10:e1004004 pubmed publisher
Huang C, Cao W, Liao R, Wang J, Wang Y, Tong L, et al. PP1? functionally augments the alternative splicing of CaMKII? through interaction with ASF. Am J Physiol Cell Physiol. 2014;306:C167-77 pubmed publisher
Isensee J, Diskar M, Waldherr S, Buschow R, Hasenauer J, Prinz A, et al. Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons. J Cell Sci. 2014;127:216-29 pubmed publisher
Pribiag H, Stellwagen D. TNF-? downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABA(A) receptors. J Neurosci. 2013;33:15879-93 pubmed publisher
Toledo A, Zolessi F, Arruti C. A novel effect of MARCKS phosphorylation by activated PKC: the dephosphorylation of its serine 25 in chick neuroblasts. PLoS ONE. 2013;8:e62863 pubmed publisher
Walsh J, Young M. TGF-beta regulation of focal adhesion proteins and motility of premalignant oral lesions via protein phosphatase 1. Anticancer Res. 2011;31:3159-64 pubmed
Walsh J, Young M. Interrelationship between protein phosphatase 1 and TGF-{beta} in regulating motility and cytoskeletal architecture of endothelial cells. Anticancer Res. 2010;30:4861-6 pubmed

product information

brand :

Tocris

master code :

2305

SKU :

2305/50U

product name :

Tautomycetin

description :

Selective PP1 inhibitor

target :

Protein Ser/Thr Phosphatase Inhibitors

category :

Small Molecules

unit sizes :

50 ug

purity :

95%

observed molecular weight :

606.75

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Tautomycetin is a selective inhibitor of protein phosphatase (PP)1 (IC50 values are 1.6 and 62 nM for PP1 and PP2 respectively). Reduces PDGF-induced vascular smooth muscle cell and mesangial cell proliferation without affecting fibronectin secretion and cellular kinase activation in vivo . Immunosuppressive agent; inhibits proliferation and induces apoptosis in activated T cells.

extended description :

Selective PP1 inhibitor

chemical name text :

(1R,2S,3R,6S,7S,10S,12R,15E, R,3R)-16-Ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5,14-dioxo-15,17-octadecadienyl 2,5-dihydro- -hydroxy-4-methyl-2,5-dioxo-3-furanpropanoic acid ester

formula :

C 33 H 50 O 10

formula text :

C33H50O10

cas num :

119757-73-2

USD :

405 USD

product details :

Selective PP1 inhibitor

storage :

Desiccate at -20°C