PNU 282987 | Tocris Bioscience 2303/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PNU 282987

catalog :

2303/10

quantity :

10 mg (also 50 mg)

price :

197 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Zhong C, Talmage D, Role L. Nicotine elicits prolonged calcium signaling along ventral hippocampal axons. PLoS ONE. 2013;8:e82719 pubmed publisher
Pandya A, Yakel J. Activation of the Î±7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HTâ‚a receptor antagonist. Neuropharmacology. 2013;70:35-42 pubmed publisher
Wang H, Bakshi K, Frankfurt M, Stucky A, Goberdhan M, Shah S, et al. Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A. J Neurosci. 2012;32:9773-84 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2303

SKU :

2303/10

product name :

PNU 282987

description :

Selective 7 nAChR agonist

target :

Nicotinic (a7) Receptor Agonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at RT

observed molecular weight :

264.75

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PNU 282987 is a highly selective 7 nAChR agonist (Ki = 26 nM) displaying negligible blockade of 1 1 and 3 4 nAChRs (IC50 60 u M). Found to be inactive against a panel of 32 receptors at 1 u M, except 5-HT3 receptors (Ki = 930 nM).

product keywords :

Selective 7 alpha7 a7 nAChR agonists Nicotinic Receptors Acetylcholine PNU282987 Nicotinic (a7) Receptors 2303,

extended description :

Selective 7 nAChR agonist

chemical name text :

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide

formula :

C14H17ClN2O

formula text :

C14H17ClN2O

cas num :

711085-63-1

USD :

189

USD 2025 :

197 USD

product details :

Selective 7 nAChR agonist

more info or order :

Tocris Bioscience product webpage