Sanguinarine chloride | Tocris Bioscience 2302/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Sanguinarine chloride

catalog :

2302/5

quantity :

5 mg (also 25 mg)

price :

119 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Pereira J, Chevalier C, Chaze T, Gianetto Q, Impens F, Matondo M, et al. Infection Reveals a Modification of SIRT2 Critical for Chromatin Association. Cell Rep. 2018;23:1124-1137 pubmed publisher
Kenny H, Lal Nag M, White E, Shen M, Chiang C, Mitra A, et al. Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy. Nat Commun. 2015;6:6220 pubmed publisher
Candas D, Lu C, Fan M, Chuang F, Sweeney C, Borowsky A, et al. Mitochondrial MKP1 is a target for therapy-resistant HER2-positive breast cancer cells. Cancer Res. 2014;74:7498-509 pubmed publisher
Bavaria M, Jin S, Ray R, Johnson L. The mechanism by which MEK/ERK regulates JNK and p38 activity in polyamine depleted IEC-6 cells during apoptosis. Apoptosis. 2014;19:467-79 pubmed publisher

image

image 1 :

Cat.No. 2302 - Sanguinarine chloride C20H14ClNO4 CAS No. 5578-73-4

product information

brand :

Tocris

catalog number base :

2302

SKU :

2302/5

product name :

Sanguinarine chloride

units size :

5 mg (also 25 mg)

description :

Inhibitor of protein phosphatase 2C (PP2C)

target :

Protein Ser/Thr Phosphatase Inhibitors

category :

Small Molecules

purity :

97%

observed molecular weight :

367.78

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Sanguinarine chloride is an inhibitor of protein phosphatase 2C (PP2C), selective over PP1, PP2A and PP2B in vitro . Also inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) (IC50 = 10 M). Plant alkaloid that exhibits anti-inflammatory and antioxidant activity. Blocks cell cycle in the G1 phase; inhibits cell growth in human prostate carcinoma cells.

top caption :

Inhibitor of protein phosphatase 2C (PP2C)

extended description :

Inhibitor of protein phosphatase 2C (PP2C)

chemical name text :

13-Methyl-[1,3]-benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium chloride

formula :

C20H14ClNO4

formula text :

C20H14ClNO4

cas num :

5578-73-4

USD :

119 USD

product details :

Inhibitor of protein phosphatase 2C (PP2C)

storage :

Store at +4Â°C

more info or order :

Tocris Bioscience product webpage