product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
T 0070907
catalog :
2301
quantity :
25 mg
price :
349 USD
more info or order :
citations: 5
Reference
Fellous T, De Maio F, Kalkan H, Carannante B, Boccella S, Petrosino S, et al. Phytocannabinoids promote viability and functional adipogenesis of bone marrow-derived mesenchymal stem cells through different molecular targets. Biochem Pharmacol. 2020;175:113859 pubmed publisher
Kassotis C, Masse L, Kim S, Schlezinger J, Webster T, Stapleton H. Characterization of Adipogenic Chemicals in Three Different Cell Culture Systems: Implications for Reproducibility Based on Cell Source and Handling. Sci Rep. 2017;7:42104 pubmed publisher
Bullers S, Baker S, Ingham E, Southgate J. The human tissue-biomaterial interface: a role for PPAR?-dependent glucocorticoid receptor activation in regulating the CD163+ M2 macrophage phenotype. Tissue Eng Part A. 2014;20:2390-401 pubmed publisher
Hamtiaux L, Masquelier J, Muccioli G, Bouzin C, Feron O, Gallez B, et al. The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action. BMC Cancer. 2012;12:92 pubmed publisher
Hamtiaux L, Hansoulle L, Dauguet N, Muccioli G, Gallez B, Lambert D. Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism. PLoS ONE. 2011;6:e26823 pubmed publisher
product information
brand :
Tocris
master code :
2301
SKU :
2301/25
product name :
T 0070907
description :
Highly potent and selective covalent PPAR antagonist
target :
PPAR gamma Receptor Antagonists
category :
Small Molecules
unit size :
25 mg
purity :
99%
observed molecular weight :
277.67
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Potent and selective irreversible PPAR antagonist (IC50 = 1 nM). Displays 800-fold selectivity for PPAR over PPAR and PPAR . Blocks transcriptional activity of PPAR in vitro and inhibits rosiglitazone-induced adipogenesis.
catalog number base :
2301
product keywords :
potent selective PPAR PPARgamma antagonists Peroxisome Proliferator-activating Receptors T0070907 PPARgamma Receptors 2301,
extended description :
Highly potent and selective covalent PPAR antagonist
chemical name text :
2-Chloro-5-nitro-N-4-pyridinylbenzamide
formula :
C 12 H 8 N 3 O 3 Cl
formula text :
C12H8N3O3Cl
cas num :
313516-66-4
2020 USD :
335
2021 USD :
349 USD
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK