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company name :
Tocris Bioscience
product type :
chemical
product name :
Prostaglandin E2
catalog :
2296/10
quantity :
10 mg
price :
216 USD
more info or order :
citations: 28
Reference
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Gassmann H, Schneider K, Evdokimova V, Ruzanov P, Schober S, Xue B, et al. Ewing Sarcoma-Derived Extracellular Vesicles Impair Dendritic Cell Maturation and Function. Cells. 2021;10: pubmed publisher
Nilsson K, Henning P, El Shahawy M, Nethander M, Andersen T, Ejersted C, et al. RSPO3 is important for trabecular bone and fracture risk in mice and humans. Nat Commun. 2021;12:4923 pubmed publisher
Gutjahr A, Papagno L, Vernejoul F, Lioux T, Jospin F, Chanut B, et al. New chimeric TLR7/NOD2 agonist is a potent adjuvant to induce mucosal immune responses. EBioMedicine. 2020;58:102922 pubmed publisher
Post Y, Puschhof J, Beumer J, Kerkkamp H, de Bakker M, Slagboom J, et al. Snake Venom Gland Organoids. Cell. 2020;180:233-247.e21 pubmed publisher
Colomer C, Margalef P, Villanueva A, Vert A, Pecharroman I, Sole L, et al. IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer. Mol Cell. 2019;75:669-682.e5 pubmed publisher
Somerville T, Xu Y, Miyabayashi K, Tiriac H, Cleary C, Maia Silva D, et al. TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma. Cell Rep. 2018;25:1741-1755.e7 pubmed publisher
Hill S, Decker B, Roberts E, Horowitz N, Muto M, Worley M, et al. Prediction of DNA Repair Inhibitor Response in Short-Term Patient-Derived Ovarian Cancer Organoids. Cancer Discov. 2018;8:1404-1421 pubmed publisher
Dutton L, Dudhia J, Catchpole B, Hodgkiss Geere H, Werling D, Connolly D. Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor. Sci Rep. 2018;8:13351 pubmed publisher
Senger S, Ingano L, Freire R, Anselmo A, Zhu W, Sadreyev R, et al. Human Fetal-Derived Enterospheres Provide Insights on Intestinal Development and a Novel Model to Study Necrotizing Enterocolitis (NEC). Cell Mol Gastroenterol Hepatol. 2018;5:549-568 pubmed publisher
Puca L, Bareja R, Prandi D, Shaw R, Benelli M, Karthaus W, et al. Patient derived organoids to model rare prostate cancer phenotypes. Nat Commun. 2018;9:2404 pubmed publisher
Sherman H, Gitschier H, Rossi A. A Novel Three-Dimensional Immune Oncology Model for High-Throughput Testing of Tumoricidal Activity. Front Immunol. 2018;9:857 pubmed publisher
Ye Y, Vattai A, Ditsch N, Kuhn C, Rahmeh M, Mahner S, et al. Prostaglandin E2 receptor 3 signaling is induced in placentas with unexplained recurrent pregnancy losses. Endocr Connect. 2018;7:749-761 pubmed publisher
Zhu J, Trillsch F, Mayr D, Kuhn C, Rahmeh M, Hofmann S, et al. Prostaglandin receptor EP3 regulates cell proliferation and migration with impact on survival of endometrial cancer patients. Oncotarget. 2018;9:982-994 pubmed publisher
Sachamitr P, Leishman A, Davies T, Fairchild P. Directed Differentiation of Human Induced Pluripotent Stem Cells into Dendritic Cells Displaying Tolerogenic Properties and Resembling the CD141+ Subset. Front Immunol. 2017;8:1935 pubmed publisher
Ma L, Li J, Nie Q, Zhang Q, Liu S, Ge D, et al. Organoid culture of human prostate cancer cell lines LNCaP and C4-2B. Am J Clin Exp Urol. 2017;5:25-33 pubmed
Qiang L, Sample A, Shea C, Soltani K, Macleod K, He Y. Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis. Autophagy. 2017;: pubmed publisher
Roe J, Hwang C, Somerville T, Milazzo J, Lee E, Da Silva B, et al. Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis. Cell. 2017;170:875-888.e20 pubmed publisher
Langdale C, Hokanson J, Sridhar A, Grill W. Stimulation of the pelvic nerve increases bladder capacity in the prostaglandin E2 rat model of overactive bladder. Am J Physiol Renal Physiol. 2017;313:F657-F665 pubmed publisher
Al Taei S, Salimu J, Spary L, Clayton A, Lester J, Tabi Z. Prostaglandin E2-mediated adenosinergic effects on CD14+ cells: Self-amplifying immunosuppression in cancer. Oncoimmunology. 2017;6:e1268308 pubmed publisher
Drost J, Karthaus W, Gao D, Driehuis E, Sawyers C, Chen Y, et al. Organoid culture systems for prostate epithelial and cancer tissue. Nat Protoc. 2016;11:347-58 pubmed publisher
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product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2296
SKU :
2296/10
product name :
Prostaglandin E2
description :
Promotes HSCs expansion; increases HSCs engraftment; also endogenous prostaglandin
target :
Prostanoid Receptor Agonists
unit size :
10 mg
category :
Small Molecules
purity :
98%
storage :
Store at -20°C
observed molecular weight :
352.47
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Prostaglandin E2 is an endogenous prostaglandin and primary product of arachidonic acid/cyclooxygenase pathway. Prostaglandin E2 binds with high affinity to EP1, EP2, EP3 and EP4 receptors (Kd values range between ~ 1 - 10 nM). Prostaglandin E2 influences a wide range of processes including inflammation, vasodilation, smooth muscle relaxation, fertility, gastric mucosal integrity and platelet aggregation. Prostaglandin E2 regulates vertebrate hematopoietic stem cell (HSC) homeostasis, acts as viral transduction enhancer and is tumorigenic in some cancers.
product keywords :
endogenous prostanoid EP1 EP2 EP3 EP4 Receptors prostaglandins prostacyclins eicosanoids ProstaglandinE2 stem cells e2 PGE2 hematopoietic haematopoietic stem cells HSC PGE2 Prostanoid Receptors Stem Cell Signaling Stem Cell Proliferation Organoids Viral Transduction Enhancers Hematopoietic Stem Cells 2296,
extended description :
Promotes HSCs expansion; increases HSCs engraftment; also endogenous prostaglandin
chemical name text :
(5Z,11 ,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1oic acid
formula :
C20H32O5
formula text :
C20H32O5
cas num :
363-24-6
USD :
207
USD 2025 :
216 USD
product details :
Promotes HSCs expansion; increases HSCs engraftment; also endogenous prostaglandin
alt names :
PGE2
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK