Zebularine | Tocris Bioscience 2293 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Zebularine

catalog :

2293

quantity :

10 mg

price :

154 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Zou Y, Hu X, Schewitz Bowers L, Stimpson M, Miao L, Ge X, et al. The DNA Methylation Inhibitor Zebularine Controls CD4+ T Cell Mediated Intraocular Inflammation. Front Immunol. 2019;10:1950 pubmed publisher
Soltoff S, Lannon W. Activation of ERK1/2 by store-operated calcium entry in rat parotid acinar cells. PLoS ONE. 2013;8:e72881 pubmed publisher
Biergans S, Jones J, Treiber N, Galizia C, Szyszka P. DNA methylation mediates the discriminatory power of associative long-term memory in honeybees. PLoS ONE. 2012;7:e39349 pubmed publisher
Trowbridge J, Sinha A, Zhu N, Li M, Armstrong S, Orkin S. Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. Genes Dev. 2012;26:344-9 pubmed publisher

product information

brand :

Tocris

master code :

2293

SKU :

2293/10

product name :

Zebularine

description :

DNA methyltransferase and cytidine deaminase inhibitor

target :

Methyltransferase Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

99%

observed molecular weight :

228.2

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC50 = 120 u M) and re-activates silenced genes in T24 bladder carcinoma cells. Inhibits cytidine deaminase (Ki ~ 2 u M); induces differentiation of mesenchymal stem cells into cardiomyocytes.

catalog number base :

2293

product keywords :

DNA methyltransferase inhibitors inhibits Transferases cytidine deaminases NSC309132 dnmt cardiomyocyte differentiation mesenchymal stem cells epigenetics NSC 309132 DNA Methyltransferases Deaminases Cardiomyocyte Stem Cells Mesenchymal Stem Cells 2293,

extended description :

DNA methyltransferase and cytidine deaminase inhibitor

chemical name text :

1- -D-Ribofuranosyl-2(1H)-pyrimidinone

formula :

C 9 H 12 N 2 O 5

formula text :

C9H12N2O5

cas num :

10/6/90

2020 USD :

154

2021 USD :

154 USD

alt names :

NSC 309132

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage