2293/10 | Tocris Bioscience 2293/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

2293/10

catalog :

2293/10

quantity :

10 mg

price :

194 USD

citations: 4

Reference
Zou Y, Hu X, Schewitz Bowers L, Stimpson M, Miao L, Ge X, et al. The DNA Methylation Inhibitor Zebularine Controls CD4+ T Cell Mediated Intraocular Inflammation. Front Immunol. 2019;10:1950 pubmed publisher
Soltoff S, Lannon W. Activation of ERK1/2 by store-operated calcium entry in rat parotid acinar cells. PLoS ONE. 2013;8:e72881 pubmed publisher
Biergans S, Jones J, Treiber N, Galizia C, Szyszka P. DNA methylation mediates the discriminatory power of associative long-term memory in honeybees. PLoS ONE. 2012;7:e39349 pubmed publisher
Trowbridge J, Sinha A, Zhu N, Li M, Armstrong S, Orkin S. Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. Genes Dev. 2012;26:344-9 pubmed publisher

product information

master code :

2293

SKU :

2293/10

product name :

Zebularine

unit size :

10 mg

description :

DNA methyltransferase and cytidine deaminase inhibitor

target :

Methyltransferase Inhibitors

category :

Small Molecules

purity :

99%

observed molecular weight :

228.2

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Zebularine is an orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC50 = 120 u M) and re-activates silenced genes in T24 bladder carcinoma cells. Inhibits cytidine deaminase (Ki ~ 2 u M); induces differentiation of mesenchymal stem cells into cardiomyocytes.

top caption :

DNA methyltransferase and cytidine deaminase inhibitor

extended description :

DNA methyltransferase and cytidine deaminase inhibitor

chemical name text :

1- -D-Ribofuranosyl-2(1H)-pyrimidinone

formula :

C9H12N2O5

formula text :

C9H12N2O5

cas num :

10/6/90

USD :

194 USD

product details :

DNA methyltransferase and cytidine deaminase inhibitor

alt names :

NSC 309132

storage :

Desiccate at RT