Go 6983 | Tocris Bioscience 2285 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Go 6983

catalog :

2285

quantity :

1 mg (also 10 mg)

price :

118 USD

more info or order :

Tocris Bioscience product webpage

citations: 26

Reference
Mclaurin J, Weiner O. Multiple sources of signal amplification within the B-cell Ras/MAPK pathway. Mol Biol Cell. 2019;30:1610-1620 pubmed publisher
Rostovskaya M, Stirparo G, Smith A. Capacitation of human naïve pluripotent stem cells for multi-lineage differentiation. Development. 2019;146: pubmed publisher
Messmer T, von Meyenn F, Savino A, Santos F, Mohammed H, Lun A, et al. Transcriptional Heterogeneity in Naive and Primed Human Pluripotent Stem Cells at Single-Cell Resolution. Cell Rep. 2019;26:815-824.e4 pubmed publisher
Schaffer T, Smith J, Cook E, Phan T, Margolis S. PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5. Cell Rep. 2018;25:2470-2483.e8 pubmed publisher
Liu T, Shi Y, Chan M, Peng G, Zhang Q, Sun X, et al. Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish. Transl Psychiatry. 2018;8:232 pubmed publisher
Fang F, Xia N, Angulo B, Carey J, Cady Z, Durruthy Durruthy J, et al. A distinct isoform of ZNF207 controls self-renewal and pluripotency of human embryonic stem cells. Nat Commun. 2018;9:4384 pubmed publisher
Carriba P, Davies A. CD40 is a major regulator of dendrite growth from developing excitatory and inhibitory neurons. elife. 2017;6: pubmed publisher
Augustin H, McGourty K, Allen M, Madem S, Adcott J, Kerr F, et al. Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies. PLoS Biol. 2017;15:e2001655 pubmed publisher
Zhang Z, Meszaros G, He W, Xu Y, de Fatima Magliarelli H, Mailly L, et al. Protein kinase D at the Golgi controls NLRP3 inflammasome activation. J Exp Med. 2017;214:2671-2693 pubmed publisher
Tuvikene J, Pruunsild P, Orav E, Esvald E, Timmusk T. AP-1 Transcription Factors Mediate BDNF-Positive Feedback Loop in Cortical Neurons. J Neurosci. 2016;36:1290-305 pubmed publisher
Li X, Rhee D, Malhotra R, Mayeur C, Hurst L, Ager E, et al. Progesterone receptor membrane component-1 regulates hepcidin biosynthesis. J Clin Invest. 2016;126:389-401 pubmed publisher
Shakiba N, White C, Lipsitz Y, Yachie Kinoshita A, Tonge P, Hussein S, et al. CD24 tracks divergent pluripotent states in mouse and human cells. Nat Commun. 2015;6:7329 pubmed publisher
Devinney M, Fields D, Huxtable A, Peterson T, Dale E, Mitchell G. Phrenic long-term facilitation requires PKCÎ¸ activity within phrenic motor neurons. J Neurosci. 2015;35:8107-17 pubmed publisher
Toda A, Huganir R. Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38. Proc Natl Acad Sci U S A. 2015;112:6712-7 pubmed publisher
Kuan C, Yee Y, See Too W, Few L. Ets and GATA transcription factors play a critical role in PMA-mediated repression of the ckÎ² promoter via the protein kinase C signaling pathway. PLoS ONE. 2014;9:e113485 pubmed publisher
Yi C, Allen J, Russo B, Lee S, Heindl J, Baxt L, et al. Systematic analysis of bacterial effector-postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domain interactions demonstrates Shigella OspE protein promotes protein kinase C activation via PDLIM proteins. J Biol Chem. 2014;289:30101-13 pubmed publisher
Cavaliere F, Benito Muñoz M, Panicker M, Matute C. NMDA modulates oligodendrocyte differentiation of subventricular zone cells through PKC activation. Front Cell Neurosci. 2013;7:261 pubmed publisher
Gafni O, Weinberger L, Mansour A, Manor Y, Chomsky E, Ben Yosef D, et al. Derivation of novel human ground state naive pluripotent stem cells. Nature. 2013;504:282-6 pubmed publisher
Pakpour N, Camp L, Smithers H, Wang B, Tu Z, Nadler S, et al. Protein kinase C-dependent signaling controls the midgut epithelial barrier to malaria parasite infection in anopheline mosquitoes. PLoS ONE. 2013;8:e76535 pubmed publisher
van Vliet S, Vuist I, Lenos K, Tefsen B, Kalay H, Garcia Vallejo J, et al. Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL). J Biol Chem. 2013;288:27519-32 pubmed publisher
Rajendran G, Dutta D, Hong J, Paul A, Saha B, Mahato B, et al. Inhibition of protein kinase C signaling maintains rat embryonic stem cell pluripotency. J Biol Chem. 2013;288:24351-62 pubmed publisher
Atwood S, Li M, Lee A, Tang J, Oro A. GLI activation by atypical protein kinase C ?/? regulates the growth of basal cell carcinomas. Nature. 2013;494:484-8 pubmed publisher
Garrett A, Schreiner D, Lobas M, Weiner J. ?-protocadherins control cortical dendrite arborization by regulating the activity of a FAK/PKC/MARCKS signaling pathway. Neuron. 2012;74:269-76 pubmed publisher
Scarisbrick I, Radulovic M, Burda J, Larson N, Blaber S, Giannini C, et al. Kallikrein 6 is a novel molecular trigger of reactive astrogliosis. Biol Chem. 2012;393:355-67 pubmed publisher
Baskin R, Sayeski P. Angiotensin II mediates cell survival through upregulation and activation of the serum and glucocorticoid inducible kinase 1. Cell Signal. 2012;24:435-42 pubmed publisher
Dutta D, Ray S, Home P, Larson M, Wolfe M, Paul S. Self-renewal versus lineage commitment of embryonic stem cells: protein kinase C signaling shifts the balance. Stem Cells. 2011;29:618-28 pubmed publisher

product information

brand :

Tocris

master code :

2285

SKU :

2285/1

product name :

Go 6983

description :

Broad spectrum PKC inhibitor

target :

Protein Kinase C Inhibitors

category :

Small Molecules

unit size :

1 mg (also 10 mg)

purity :

98%

observed molecular weight :

442.51

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Broad spectrum protein kinase C (PKC) inhibitor (IC50 values are 7, 7, 6, 10, 60 and 20000 nM for PKC , PKC , PKC , PKC , PKC and PKC u respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. Optimizes na ve human pluripotent stem cell growth and viability following na ve cell derivation from primed ESCs and iPSCs using na ve human stem cell medium (NHSM).

catalog number base :

2285

product keywords :

Broad spectrum PKC inhibitors inhibits Protein Kinases C Go6983 Goe6983 stem cells naive Goe 6983 Protein Kinase C Stem Cell Proliferation 2285,

extended description :

Broad spectrum PKC inhibitor

chemical name text :

3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

formula :

C 26 H 26 N 4 O 3

formula text :

C26H26N4O3

cas num :

133053-19-7

2020 USD :

115

2021 USD :

118 USD

alt names :

Goe 6983

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage