SEW 2871 | Tocris Bioscience 2284 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SEW 2871

catalog :

2284

quantity :

10 mg (also 50 mg)

price :

85 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Matsushima Nishiwaki R, Yamada N, Fukuchi K, Kozawa O. Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2. PLoS ONE. 2018;13:e0209050 pubmed publisher
O Sullivan M, Hirota N, Martin J. Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor ?B in BEAS-2B cells. PLoS ONE. 2014;9:e95566 pubmed publisher
Beckham T, Lu P, Cheng J, Zhao D, Turner L, Zhang X, et al. Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B. Int J Cancer. 2012;131:2034-43 pubmed publisher
Zhang G, Xu S, Qian Y, He P. Sphingosine-1-phosphate prevents permeability increases via activation of endothelial sphingosine-1-phosphate receptor 1 in rat venules. Am J Physiol Heart Circ Physiol. 2010;299:H1494-504 pubmed publisher
Kim M, Kim M, Park S, Pitson S, Lee H. Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generation. Am J Nephrol. 2010;31:353-62 pubmed publisher
Frias M, Lang U, Gerber Wicht C, James R. Native and reconstituted HDL protect cardiomyocytes from doxorubicin-induced apoptosis. Cardiovasc Res. 2010;85:118-26 pubmed publisher

product information

brand :

Tocris

master code :

2284

SKU :

2284/10

product name :

SEW 2871

description :

Cell-permeable, selective S1P1 receptor agonist

target :

Sphingosine-1-phosphate Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

440.36

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Novel, potent and selective sphingosine-1-phosphate 1 (S1P1) receptor agonist. Activates S1P1 receptor with an EC50 of 13 nM, but does not activate S1P2, S1P3, S1P4 or S1P5 receptors at concentrations up to 10 u M. Cell-permeable and active in vivo .

catalog number base :

2284

product keywords :

Cell-permeable selective S1P1 receptors agonists EDG1 sphingosine-1-phosphate SEW2871 Sphingosine-1-phosphate Receptors 2284,

extended description :

Cell-permeable, selective S1P1 receptor agonist

chemical name text :

5-[4-Phenyl-5-(trifluoromethyl)thiophen-2-yl]-3-[3-(trifluoromethyl)phenyl]1,2,4-oxadiazole

formula :

C 20 H 10 F 6 N 2 OS

formula text :

C20H10F6N2OS

cas num :

256414-75-2

2020 USD :

2021 USD :

85 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage