SEW 2871 | Tocris Bioscience 2284/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SEW 2871

catalog :

2284/10

quantity :

10 mg (also 50 mg)

price :

108 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Matsushima Nishiwaki R, Yamada N, Fukuchi K, Kozawa O. Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2. PLoS ONE. 2018;13:e0209050 pubmed publisher
Samarska I, Bouma H, Buikema H, Mungroop H, Houwertjes M, Absalom A, et al. S1P1 receptor modulation preserves vascular function in mesenteric and coronary arteries after CPB in the rat independent of depletion of lymphocytes. PLoS ONE. 2014;9:e97196 pubmed publisher
O Sullivan M, Hirota N, Martin J. Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor ?B in BEAS-2B cells. PLoS ONE. 2014;9:e95566 pubmed publisher
Beckham T, Lu P, Cheng J, Zhao D, Turner L, Zhang X, et al. Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B. Int J Cancer. 2012;131:2034-43 pubmed publisher
Zhang G, Xu S, Qian Y, He P. Sphingosine-1-phosphate prevents permeability increases via activation of endothelial sphingosine-1-phosphate receptor 1 in rat venules. Am J Physiol Heart Circ Physiol. 2010;299:H1494-504 pubmed publisher
Kim M, Kim M, Park S, Pitson S, Lee H. Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generation. Am J Nephrol. 2010;31:353-62 pubmed publisher
Frias M, Lang U, Gerber Wicht C, James R. Native and reconstituted HDL protect cardiomyocytes from doxorubicin-induced apoptosis. Cardiovasc Res. 2010;85:118-26 pubmed publisher

product information

brand :

Tocris

catalog number base :

2284

SKU :

2284/10

product name :

SEW 2871

units size :

10 mg (also 50 mg)

description :

Cell-permeable, selective S1P1 receptor agonist

target :

Sphingosine-1-phosphate Receptor Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

440.36

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SEW 2871 is a novel, potent and selective sphingosine-1-phosphate 1 (S1P1) receptor agonist. Activates S1P1 receptor with an EC50 of 13 nM, but does not activate S1P2, S1P3, S1P4 or S1P5 receptors at concentrations up to 10 u M. Cell-permeable and active in vivo .

top caption :

Cell-permeable, selective S1P1 receptor agonist

extended description :

Cell-permeable, selective S1P1 receptor agonist

chemical name text :

5-[4-Phenyl-5-(trifluoromethyl)thiophen-2-yl]-3-[3-(trifluoromethyl)phenyl]1,2,4-oxadiazole

formula :

C20H10F6N2OS

formula text :

C20H10F6N2OS

cas num :

256414-75-2

USD :

108 USD

product details :

Cell-permeable, selective S1P1 receptor agonist

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage