Ro 08-2750 | Tocris Bioscience 2272/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Ro 08-2750

catalog :

2272/1

quantity :

1 mg (also 10 mg, 50 mg)

price :

127 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 2272 - Ro 08-2750 C13H10N4O3 CAS No. 37854-59-4

product information

brand :

Tocris

MasterCode :

2272

SKU :

2272/1

product name :

Ro 08-2750

target :

Trk Receptor Inhibitors

category :

Small Molecules

unit size :

1 mg (also 10 mg, 50 mg)

purity :

95%

observed molecular weight :

270.24

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Ro 08-2750 is a non-peptide inhibitor of NGF that binds the NGF dimer (KD ~ 1 u M) possibly causing a conformational change. Selectively inhibits binding of NGF to p75NTR at submicromolar concentrations, and to both p75NTR and TrkA at concentrations 5 u M. Prevents NGF-induced apoptosis in SK-N-MC cells. Suppresses cancer cell proliferation via regulation of Hippo signaling aand YAP phosphorylation.

extended description :

Inhibits NGF binding to p75NTR and TrkA

chemical name text :

2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde

formula :

C 13 H 10 N 4 O 3

formula text :

C13H10N4O3

cas num :

37854-59-4

USD :

127 USD

product details :

Inhibits NGF binding to p75NTR and TrkA

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage