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company name :
Tocris Bioscience
product type :
chemical
product name :
SCH 58261
catalog :
2270/10
quantity :
10 mg (also 50 mg)
price :
272 USD
more info or order :
citations: 45
Reference
Xu X, Beleza R, Gon xe7 alves F, Valbuena S, Al xe7 ada Morais S, Gon xe7 alves N, et al. Adenosine A2A receptors control synaptic remodeling in the adult brain. Sci Rep. 2022;12:14690 pubmed publisher
De Marchi E, Pegoraro A, Turiello R, Di Virgilio F, Morello S, Adinolfi E. A2A Receptor Contributes to Tumor Progression in P2X7 Null Mice. Front Cell Dev Biol. 2022;10:876510 pubmed publisher
Lin C, Lai H, Chen H, Siew J, Hsiao C, Chang H, et al. Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D2 and adenosine A2A receptors. Transl Psychiatry. 2019;9:209 pubmed publisher
Aires I, Boia R, Rodrigues Neves A, Madeira M, Marques C, Ambrósio A, et al. Blockade of microglial adenosine A2A receptor suppresses elevated pressure-induced inflammation, oxidative stress, and cell death in retinal cells. Glia. 2019;67:896-914 pubmed publisher
Leffa D, Pandolfo P, Gonçalves N, Machado N, de Souza C, Real J, et al. Adenosine A2A Receptors in the Rat Prelimbic Medial Prefrontal Cortex Control Delay-Based Cost-Benefit Decision Making. Front Mol Neurosci. 2018;11:475 pubmed publisher
Liu G, Zhang W, Guo J, Kong F, Zhou S, Chen S, et al. Adenosine binds predominantly to adenosine receptor A1 subtype in astrocytes and mediates an immunosuppressive effect. Brain Res. 2018;1700:47-55 pubmed publisher
Kinoshita M, Hirayama Y, Fujishita K, Shibata K, Shinozaki Y, Shigetomi E, et al. Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes. EBioMedicine. 2018;32:72-83 pubmed publisher
Salimu J, Webber J, Gurney M, Al Taei S, Clayton A, Tabi Z. Dominant immunosuppression of dendritic cell function by prostate-cancer-derived exosomes. J Extracell Vesicles. 2017;6:1368823 pubmed publisher
Cheng R, Segala E, Robertson N, Deflorian F, Doré A, Errey J, et al. Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity. Structure. 2017;25:1275-1285.e4 pubmed publisher
Al Taei S, Salimu J, Spary L, Clayton A, Lester J, Tabi Z. Prostaglandin E2-mediated adenosinergic effects on CD14+ cells: Self-amplifying immunosuppression in cancer. Oncoimmunology. 2017;6:e1268308 pubmed publisher
Xiong L, Jung J, Guo H, Pan J, Sun X, Mei L, et al. Osteoblastic Lrp4 promotes osteoclastogenesis by regulating ATP release and adenosine-A2AR signaling. J Cell Biol. 2017;216:761-778 pubmed publisher
Nadal L, Garcia N, Hurtado E, Simó A, Tomas M, Lanuza M, et al. Presynaptic muscarinic acetylcholine autoreceptors (M1, M2 and M4 subtypes), adenosine receptors (A1 and A2A) and tropomyosin-related kinase B receptor (TrkB) modulate the developmental synapse elimination process at the neuromuscular junction. Mol Brain. 2016;9:67 pubmed publisher
Perez Aso M, Montesinos M, Mediero A, Wilder T, Schafer P, Cronstein B. Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors. Arthritis Res Ther. 2015;17:249 pubmed publisher
Madeira M, Elvas F, Boia R, Gonçalves F, Cunha R, Ambrósio A, et al. Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure. J Neuroinflammation. 2015;12:115 pubmed publisher
Stoddart L, Johnstone E, Wheal A, Goulding J, Robers M, Machleidt T, et al. Application of BRET to monitor ligand binding to GPCRs. Nat Methods. 2015;12:661-663 pubmed publisher
Kermanian F, Soleimani M, Pourheydar B, Samzadeh Kermani A, Mohammadzadeh F, Mehdizadeh M. Effects of adenosine A2a receptor agonist and antagonist on cerebellar nuclear factor-kB expression preceded by MDMA toxicity. Med J Islam Repub Iran. 2014;28:120 pubmed
Zhu G, Liu Y, Wang Y, Bi X, Baudry M. Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways. J Neurosci. 2015;35:621-33 pubmed publisher
Wydra K, Suder A, Borroto Escuela D, Filip M, Fuxe K. On the role of Aâ‚‚A and Dâ‚‚ receptors in control of cocaine and food-seeking behaviors in rats. Psychopharmacology (Berl). 2015;232:1767-78 pubmed publisher
Haanes K, Edvinsson L. Expression and characterization of purinergic receptors in rat middle meningeal artery-potential role in migraine. PLoS ONE. 2014;9:e108782 pubmed publisher
Chen Z, Xiong C, Pancyr C, Stockwell J, Walz W, Cayabyab F. Prolonged adenosine A1 receptor activation in hypoxia and pial vessel disruption focal cortical ischemia facilitates clathrin-mediated AMPA receptor endocytosis and long-lasting synaptic inhibition in rat hippocampal CA3-CA1 synapses: differential re. J Neurosci. 2014;34:9621-43 pubmed publisher
Häusler S, Del Barrio I, Diessner J, Stein R, Strohschein J, Honig A, et al. Anti-CD39 and anti-CD73 antibodies A1 and 7G2 improve targeted therapy in ovarian cancer by blocking adenosine-dependent immune evasion. Am J Transl Res. 2014;6:129-39 pubmed
Mediavilla Varela M, Luddy K, Noyes D, Khalil F, Neuger A, Soliman H, et al. Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth. Cancer Biol Ther. 2013;14:860-8 pubmed publisher
Augusto E, Matos M, Sevigny J, El Tayeb A, Bynoe M, Muller C, et al. Ecto-5'-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions. J Neurosci. 2013;33:11390-9 pubmed publisher
Bao Y, Chen Y, Ledderose C, Li L, Junger W. Pannexin 1 channels link chemoattractant receptor signaling to local excitation and global inhibition responses at the front and back of polarized neutrophils. J Biol Chem. 2013;288:22650-7 pubmed publisher
Chen M, Su W, Lin X, Guo Z, Wang J, Zhang Q, et al. Adoptive transfer of human gingiva-derived mesenchymal stem cells ameliorates collagen-induced arthritis via suppression of Th1 and Th17 cells and enhancement of regulatory T cell differentiation. Arthritis Rheum. 2013;65:1181-93 pubmed publisher
Hikida T, Yawata S, Yamaguchi T, Danjo T, Sasaoka T, Wang Y, et al. Pathway-specific modulation of nucleus accumbens in reward and aversive behavior via selective transmitter receptors. Proc Natl Acad Sci U S A. 2013;110:342-7 pubmed publisher
Wu M, Sahbaie P, Zheng M, Lobato R, Boison D, Clark J, et al. Opiate-induced changes in brain adenosine levels and narcotic drug responses. Neuroscience. 2013;228:235-42 pubmed publisher
Diógenes M, Neves Tomé R, Fucile S, Martinello K, Scianni M, Theofilas P, et al. Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase. Cereb Cortex. 2014;24:67-80 pubmed publisher
Mills J, Alabanza L, Mahamed D, Bynoe M. Extracellular adenosine signaling induces CX3CL1 expression in the brain to promote experimental autoimmune encephalomyelitis. J Neuroinflammation. 2012;9:193 pubmed
Kan Y, Okabayashi T, Yokota S, Yamamoto S, Fujii N, Yamashita T. Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway. J Virol. 2012;86:10338-46 pubmed publisher
Lee Y, Yang Y, Huang C, Kuo T, Lin J, Yang D, et al. When cytokinin, a plant hormone, meets the adenosine A2A receptor: a novel neuroprotectant and lead for treating neurodegenerative disorders?. PLoS ONE. 2012;7:e38865 pubmed publisher
Mills J, Kim D, Krenz A, Chen J, Bynoe M. A2A adenosine receptor signaling in lymphocytes and the central nervous system regulates inflammation during experimental autoimmune encephalomyelitis. J Immunol. 2012;188:5713-22 pubmed publisher
Warren C, Calabrese G, Li Y, Pawlowski S, Figler R, Rieger J, et al. Effects of adenosine A?A receptor activation and alanyl-glutamine in Clostridium difficile toxin-induced ileitis in rabbits and cecitis in mice. BMC Infect Dis. 2012;12:13 pubmed publisher
Carman A, Mills J, Krenz A, Kim D, Bynoe M. Adenosine receptor signaling modulates permeability of the blood-brain barrier. J Neurosci. 2011;31:13272-80 pubmed publisher
Teng B, Mustafa S. A(2A) adenosine receptor-mediated increase in coronary flow in hyperlipidemic APOE-knockout mice. J Exp Pharmacol. 2011;2011:59-68 pubmed
Zhan E, McIntosh V, Lasley R. Adenosine A?A and A?B receptors are both required for adenosine A? receptor-mediated cardioprotection. Am J Physiol Heart Circ Physiol. 2011;301:H1183-9 pubmed publisher
Napolitano F, Bonito Oliva A, Federici M, Carta M, Errico F, Magara S, et al. Role of aberrant striatal dopamine D1 receptor/cAMP/protein kinase A/DARPP32 signaling in the paradoxical calming effect of amphetamine. J Neurosci. 2010;30:11043-56 pubmed publisher
Higley M, Sabatini B. Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors. Nat Neurosci. 2010;13:958-66 pubmed publisher
Garavaglia A, Moiana A, Camnasio S, Bolognini D, Papait R, Rigamonti D, et al. Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates. BMC Neurosci. 2010;11:7 pubmed publisher
Xi J, McIntosh R, Shen X, Lee S, Chanoit G, Criswell H, et al. Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts. J Mol Cell Cardiol. 2009;47:684-90 pubmed publisher
Pugliese A, Traini C, Cipriani S, Gianfriddo M, Mello T, Giovannini M, et al. The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slices. Br J Pharmacol. 2009;157:818-30 pubmed publisher
Wilson J, Ross W, Agbai O, Frazier R, Figler R, Rieger J, et al. The A2B adenosine receptor impairs the maturation and immunogenicity of dendritic cells. J Immunol. 2009;182:4616-23 pubmed publisher
Alam M, Kurtz C, Wilson J, Burnette B, Wiznerowicz E, Ross W, et al. A2A adenosine receptor (AR) activation inhibits pro-inflammatory cytokine production by human CD4+ helper T cells and regulates Helicobacter-induced gastritis and bacterial persistence. Mucosal Immunol. 2009;2:232-42 pubmed publisher
Shen W, Flajolet M, Greengard P, Surmeier D. Dichotomous dopaminergic control of striatal synaptic plasticity. Science. 2008;321:848-51 pubmed publisher
Guerreiro S, Toulorge D, Hirsch E, Marien M, Sokoloff P, Michel P. Paraxanthine, the primary metabolite of caffeine, provides protection against dopaminergic cell death via stimulation of ryanodine receptor channels. Mol Pharmacol. 2008;74:980-9 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2270
SKU :
2270/10
product name :
SCH 58261
description :
Potent, highly selective A2A antagonist
target :
Adenosine A2a Receptor Antagonists
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
99%
storage :
Store at RT
observed molecular weight :
345.36
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
SCH 58261 is a potent and selective A2A adenosine receptor competitive antagonist (Ki = 1.3 nM). Displays 323-, 53- and 100-fold selectivity over A1, A2B and A3 receptors, respectively. Reduces melanoma tumor growth and TGF- levels in WT and P2X7R-null mice.
product keywords :
Potent selective A2A antagonists Receptors adenosines SCH58261 Adenosine A2A Receptors 2270,
extended description :
Potent, highly selective A2A antagonist
chemical name text :
2-(2-Furanyl)-7-(2-phenylethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
formula :
C18H15N7O
formula text :
C18H15N7O
cas num :
160098-96-4
USD :
264
USD 2025 :
272 USD
product details :
Potent, highly selective A2A antagonist
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK