product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
NNC 55-0396 dihydrochloride
catalog :
2268/10
quantity :
10 mg
price :
386 USD
more info or order :
citations: 9
Reference
Mundt N, Spehr M, Lishko P. TRPV4 is the temperature-sensitive ion channel of human sperm. elife. 2018;7: pubmed publisher
Senadheera S, Bertrand P, Grayson T, Leader L, Tare M, Murphy T, et al. Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery. Am J Physiol Regul Integr Comp Physiol. 2013;305:R917-26 pubmed publisher
Schneider E, Civillico E, Wang S. Calcium-based dendritic excitability and its regulation in the deep cerebellar nuclei. J Neurophysiol. 2013;109:2282-92 pubmed publisher
Goswami S, Bucurenciu I, Jonas P. Miniature IPSCs in hippocampal granule cells are triggered by voltage-gated Ca2+ channels via microdomain coupling. J Neurosci. 2012;32:14294-304 pubmed publisher
Tzeng B, Chen Y, Huang C, Lin S, Lee K, Chen C. The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice. Cardiovasc Res. 2012;96:533-42 pubmed publisher
Baillie L, Ahn A, Mulligan S. Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres. Neuropharmacology. 2012;63:362-7 pubmed publisher
Abe H, Okazawa M, Nakanishi S. The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells. Proc Natl Acad Sci U S A. 2011;108:12497-502 pubmed publisher
Chen W, Liu I, Chang Y, Chen Y, Chen C, Yen C, et al. Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain. J Neurosci. 2010;30:10360-8 pubmed publisher
Kuo I, Ellis A, Seymour V, Sandow S, Hill C. Dihydropyridine-insensitive calcium currents contribute to function of small cerebral arteries. J Cereb Blood Flow Metab. 2010;30:1226-39 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2268
SKU :
2268/10
product name :
NNC 55-0396 dihydrochloride
description :
Highly selective CaV3.x blocker
target :
Cav3.x Channel Blockers
unit size :
10 mg
category :
Small Molecules
purity :
98%
storage :
Desiccate at RT
observed molecular weight :
564.57
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
NNC 55-0396 dihydrochloride is a highly selective T-type calcium channel blocker. Displays IC50 values of 6.8 and 100 u M for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells.
product keywords :
selective Ca2+ channel blockers T-type Calcium CaV Channels T-Type voltage-gated voltage-dependent NNC550396 dihydrochloride Cav3.x Channels 2268, Voltage-gated calcium channel blocker, voltage gated calcium channel, high-voltage activated Ca2+ channel, high voltage gated ca2+ channel
extended description :
Highly selective CaV3.x blocker
chemical name text :
(1S,2S)-2-[2-[[3-(1H-Benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl cyclopropanecarboxylate dihydrochloride
formula :
C30H38FN3O2.2HCl
formula text :
C30H38FN3O2.2HCl
cas num :
357400-13-6
USD :
370
USD 2025 :
386 USD
product details :
Highly selective CaV3.x blocker
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK