Lactacystin | Tocris Bioscience 2267/200U product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Lactacystin

catalog :

2267/200U

quantity :

200 ug

price :

376 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Warchal S, Dawson J, Carragher N. Evaluation of Machine Learning Classifiers to Predict Compound Mechanism of Action When Transferred across Distinct Cell Lines. SLAS Discov. 2019;24:224-233 pubmed publisher
Saldate J, Shiau J, Cazares V, Stuenkel E. The ubiquitin-proteasome system functionally links neuronal Tomosyn-1 to dendritic morphology. J Biol Chem. 2018;293:2232-2246 pubmed publisher
Wen J, Wen H, Gibson Corley K, Glenn K. FBG1 Is the Final Arbitrator of A1AT-Z Degradation. PLoS ONE. 2015;10:e0135591 pubmed publisher
Pandya C, Kutiyanawalla A, Turecki G, Pillai A. Glucocorticoid regulates TrkB protein levels via c-Cbl dependent ubiquitination: a decrease in c-Cbl mRNA in the prefrontal cortex of suicide subjects. Psychoneuroendocrinology. 2014;45:108-18 pubmed publisher
Ren Z, Liu M, Xue Y, Ding Z, Xue L, Zhai S, et al. A critical role for protein degradation in the nucleus accumbens core in cocaine reward memory. Neuropsychopharmacology. 2013;38:778-90 pubmed publisher
Roselli F, Livrea P, Almeida O. CDK5 is essential for soluble amyloid ?-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton. PLoS ONE. 2011;6:e23097 pubmed publisher

product information

brand :

Tocris

master code :

2267

SKU :

2267/200U

rank :

0.061

product name :

Lactacystin

description :

Cell-permeable, potent and selective proteasome inhibitor

target :

Proteasome Inhibitors

category :

Small Molecules

sizes available :

200 ug

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Lactacystin is a cell-permeable, potent and selective proteasome inhibitor. A Streptomyces metabolite that is thought to bind irreversibly to the active site N-terminal threonine residue of the catalytic -subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities. Induces neurite outgrowth in Neuro 2a neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF- B activation (IC50 = 10 u M).

extended description :

Cell-permeable, potent and selective proteasome inhibitor

chemical name text :

(2R,3S,4R)-3-Hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-2-pyrrolidinecarboxy-N-acetyl-L-cysteine thioester

formula :

C 15 H 24 N 2 O 7 S

formula text :

C15H24N2O7S

cas num :

133343-34-7

USD :

376 USD

product details :

Cell-permeable, potent and selective proteasome inhibitor

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage