Lactacystin | Tocris Bioscience 2267/200 product information

product summary

request information :

company name :

Tocris Bioscience

product type :

chemical

product name :

Lactacystin

catalog :

2267/200

quantity :

200µg

price :

275 USD

more info or order :

Tocris Bioscience product webpage

product information

CHEMISTRY :

O=C1N[C@]([C@@](SC[C@H](NC(C)=O)[C@](O)=O)=O)([C@H](C(C)C)O)[C@@H](O)[C@H]1C

Cat Number :

2267/200

Product Name :

Lactacystin

Cas Number :

[133343-34-7]

Unit Size :

200µg

Size :

200

Unit :

µg

USD :

275 USD

Primary Category :

Enzymes

Secondary Category :

Proteases

Tertiary Category :

Proteasome

Primary Action :

Cell-permeable, potent and selective proteasome inhibitor

Biological Description :

A cell-permeable, potent and selective proteasome inhibitor. A Streptomyces metabolite that is thought to bind irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities. Induces neurite outgrowth in Neuro 2a neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation (IC50 = 10 μM).

Formula :

C15H24N2O7S

Molwt :

376.42

more info or order :

Tocris Bioscience product webpage