DY131 | Tocris Bioscience 2266/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

DY131

catalog :

2266/10

quantity :

10 mg (also 50 mg)

price :

178 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Tanida T, Matsuda K, Tanaka M. Novel metabolic system for lactic acid via LRPGC1/ERRγ signaling pathway. FASEB J. 2020;34:13239-13256 pubmed publisher
Huang F, Zhang L, Wang Q, Yang Y, Li Q, Wu Y, et al. Dopamine D1 Receptors Contribute Critically to the Apomorphine-Induced Inhibition of Form-Deprivation Myopia in Mice. Invest Ophthalmol Vis Sci. 2018;59:2623-2634 pubmed publisher
Kang M, Choi H, Oshima M, Cheong J, Kim S, Lee J, et al. Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer. Nat Commun. 2018;9:1920 pubmed publisher
Heckler M, Zeleke T, Divekar S, Fernandez A, Tiek D, Woodrick J, et al. Antimitotic activity of DY131 and the estrogen-related receptor beta 2 (ERRÎ²2) splice variant in breast cancer. Oncotarget. 2016;7:47201-47220 pubmed publisher
Lu Y, Li J, Cheng J, Lubahn D. Messenger RNA profile analysis deciphers new Esrrb responsive genes in prostate cancer cells. BMC Mol Biol. 2015;16:21 pubmed publisher
Heckler M, Riggins R. ERRÎ² splice variants differentially regulate cell cycle progression. Cell Cycle. 2015;14:31-45 pubmed publisher
Poidatz D, Dos Santos E, Gronier H, Vialard F, Maury B, De Mazancourt P, et al. Trophoblast syncytialisation necessitates mitochondrial function through estrogen-related receptor-Î³ activation. Mol Hum Reprod. 2015;21:206-16 pubmed publisher
Luo Y, Kumar P, Chen C, Latham J, Wang L, Tudela C, et al. Estrogen-related receptor ? serves a role in blood pressure homeostasis during pregnancy. Mol Endocrinol. 2014;28:965-75 pubmed publisher
Byerly M, Swanson R, Wong G, Blackshaw S. Estrogen-related receptor ? deficiency alters body composition and response to restraint stress. BMC Physiol. 2013;13:10 pubmed publisher
Byerly M, Al Salayta M, Swanson R, Kwon K, Peterson J, Wei Z, et al. Estrogen-related receptor ? deletion modulates whole-body energy balance via estrogen-related receptor ? and attenuates neuropeptide Y gene expression. Eur J Neurosci. 2013;37:1033-47 pubmed publisher
Gandhari M, Frazier C, Hartenstein J, Cloix J, Bernier M, Wainer I. Identification and characterization of estrogen receptor-related receptor alpha and gamma in human glioma and astrocytoma cells. Mol Cell Endocrinol. 2010;315:314-8 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2266

SKU :

2266/10

product name :

DY131

description :

Agonist selective for estrogen-related receptors ERR and ERR

target :

Estrogen and Related Receptor Agonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Store at +4°C

observed molecular weight :

311.38

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

DY131 is a selective agonist at estrogen-related receptors ERR (EC50 range = 130 - 698 nM in vitro ) and ERR . Displays minimal activity at ERR , ER and ER at concentrations up to 30 M. In a mouse model of hepatotoxicity, DY131 protects against LPS induced liver injury. Suppresses growth and proliferation of prostate, esophagus, gastric and breast cancer cells; concentration-dependently increases cell proliferation in T98G and U87MG cells (EC50 values are 54 nM and 62 nM respectively).

product keywords :

agonists selective estrogen-related receptors ERR ERRbeta ERR ERRgamma Estrogen Receptors ERRg ERRb Estrogen and Related Receptors 2266,

extended description :

Agonist selective for estrogen-related receptors ERR and ERR

chemical name text :

N-(4-(Diethylaminobenzylidenyl)-N -(4-hydroxybenzoyl)-hydrazine

formula :

C18H21N3O2

formula text :

C18H21N3O2

cas num :

95167-41-2

USD :

176

USD 2025 :

178 USD

product details :

Agonist selective for estrogen-related receptors ERR and ERR

more info or order :

Tocris Bioscience product webpage