WRW4 | Tocris Bioscience 2262/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

WRW4

catalog :

2262/1

quantity :

1 mg

price :

141 USD

more info or order :

Tocris Bioscience product webpage

citations: 15

Reference
Amagai R, Takahashi T, Terui H, Fujimura T, Yamasaki K, Aiba S, et al. The Antimicrobial Peptide Cathelicidin Exerts Immunomodulatory Effects via Scavenger Receptors. Int J Mol Sci. 2023;24: pubmed publisher
Kienle K, Glaser K, Eickhoff S, Mihlan M, Knöpper K, Reátegui E, et al. Neutrophils self-limit swarming to contain bacterial growth in vivo. Science. 2021;372: pubmed publisher
Kuzumoto T, Tanigawa T, Higashimori A, Kitamura H, Nadatani Y, Otani K, et al. Protective role of resolvin D1, a pro-resolving lipid mediator, in nonsteroidal anti-inflammatory drug-induced small intestinal damage. PLoS ONE. 2021;16:e0250862 pubmed publisher
Cussell P, Howe M, Illingworth T, Gomez Escalada M, Milton N, Paterson A. The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically inhibited with FPR antagonists and FPR knockdown using siRNA. PLoS ONE. 2019;14:e0217815 pubmed publisher
Gussenhoven R, Klein L, Ophelders D, Habets D, Giebel B, Kramer B, et al. Annexin A1 as Neuroprotective Determinant for Blood-Brain Barrier Integrity in Neonatal Hypoxic-Ischemic Encephalopathy. J Clin Med. 2019;8: pubmed publisher
Gaudin A, Tolar M, Peters O. Lipoxin A4 Attenuates the Inflammatory Response in Stem Cells of the Apical Papilla via ALX/FPR2. Sci Rep. 2018;8:8921 pubmed publisher
Rhys H, Dell accio F, Pitzalis C, Moore A, Norling L, Perretti M. Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages. EBioMedicine. 2018;29:60-69 pubmed publisher
Hinrichs B, Matthews J, Siuda D, O Leary M, Wolfarth A, Saeedi B, et al. Serum Amyloid A1 Is an Epithelial Prorestitutive Factor. Am J Pathol. 2018;188:937-949 pubmed publisher
Ke Y, Zebda N, Oskolkova O, Afonyushkin T, Berdyshev E, Tian Y, et al. Anti-Inflammatory Effects of OxPAPC Involve Endothelial Cell-Mediated Generation of LXA4. Circ Res. 2017;121:244-257 pubmed publisher
Wenceslau C, McCarthy C, Szasz T, Goulopoulou S, Webb R. Mitochondrial N-formyl peptides induce cardiovascular collapse and sepsis-like syndrome. Am J Physiol Heart Circ Physiol. 2015;308:H768-77 pubmed publisher
Hasan M, Sultan M, Ahn W, Kim Y, Jang J, Hong C, et al. Scant Extracellular NAD Cleaving Activity of Human Neutrophils is Down-Regulated by fMLP via FPRL1. Korean J Physiol Pharmacol. 2014;18:497-502 pubmed publisher
Barnig C, Cernadas M, Dutile S, Liu X, Perrella M, Kazani S, et al. Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma. Sci Transl Med. 2013;5:174ra26 pubmed publisher
Tristão F, Rocha F, Moreira A, Cunha F, Rossi M, Silva J. 5-Lipoxygenase activity increases susceptibility to experimental Paracoccidioides brasiliensis infection. Infect Immun. 2013;81:1256-66 pubmed publisher
Leoni G, Alam A, Neumann P, Lambeth J, Cheng G, McCoy J, et al. Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest. 2013;123:443-54 pubmed publisher
Khau T, Langenbach S, Schuliga M, Harris T, Johnstone C, Anderson R, et al. Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2. FASEB J. 2011;25:483-96 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2262

SKU :

2262/1

product name :

WRW4

description :

Selective FPR2 antagonist

target :

Formyl Peptide Receptor Antagonists

unit size :

1 mg

category :

Peptides

purity :

95%

storage :

Store at -20°C

observed molecular weight :

1104.28

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

WRW4 is a selective antagonist of formyl peptide receptor 2 (FPR2) signaling. Inhibits WKYMVm binding to FPR2 (IC50 = 0.23 u M) and inhibits intracellular calcium release induced by WKYMVm, MMK 1, amyloid 42, and F peptide. Also inhibits FPR2-mediated signaling in human neutrophils; blocks chemotactic migration and superoxide generation by amyloid 42 peptide.

product keywords :

Selective FPR2 antagonists FPRL Formyl Peptide Receptors WRW4 Formyl Peptide Receptors 2262,

extended description :

Selective FPR2 antagonist

formula :

C61H65N15O6

formula text :

C61H65N15O6

cas num :

878557-55-2

USD :

135

USD 2025 :

141 USD

product details :

Selective FPR2 antagonist

alt names :

WRW4

more info or order :

Tocris Bioscience product webpage