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company name :
Tocris Bioscience
product type :
chemical
product name :
Doxorubicin hydrochloride
catalog :
2252
quantity :
10 mg (also 50 mg)
price :
162 USD
more info or order :
citations: 28
Reference
Yoon Lee J, Chung J, Hwa Kim K, Hyun An S, Yi J, Ae Kwon K, et al. Extracorporeal shock waves protect cardiomyocytes from doxorubicin-induced cardiomyopathy by upregulating survivin via the integrin-ILK-Akt-Sp1/p53 axis. Sci Rep. 2019;9:12149 pubmed publisher
Guillon J, Petit C, Moreau M, Toutain B, Henry C, Roche H, et al. Regulation of senescence escape by TSP1 and CD47 following chemotherapy treatment. Cell Death Dis. 2019;10:199 pubmed publisher
Yoon M, Kang S, Lee S, Woo T, Oh A, Park S, et al. p53 induces senescence through Lamin A/C stabilization-mediated nuclear deformation. Cell Death Dis. 2019;10:107 pubmed publisher
Kanchanapally R, Deshmukh S, Chavva S, Tyagi N, Srivastava S, Patel G, et al. Drug-loaded exosomal preparations from different cell types exhibit distinctive loading capability, yield, and antitumor efficacies: a comparative analysis. Int J Nanomedicine. 2019;14:531-541 pubmed publisher
Iriondo O, Liu Y, Lee G, Elhodaky M, Jimenez C, Li L, et al. TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis. Nat Commun. 2018;9:1994 pubmed publisher
Le Duff M, Gouju J, Jonchère B, Guillon J, Toutain B, Boissard A, et al. Regulation of senescence escape by the cdk4-EZH2-AP2M1 pathway in response to chemotherapy. Cell Death Dis. 2018;9:199 pubmed publisher
Ali R, Samman N, Al Zahrani H, Nehdi A, Rahman S, Khan A, et al. Isolation and characterization of a new naturally immortalized human breast carcinoma cell line, KAIMRC1. BMC Cancer. 2017;17:803 pubmed publisher
El Zawily A, McEwen E, Toosi B, Vizeacoumar F, Freywald T, Vizeacoumar F, et al. The EphB6 receptor is overexpressed in pediatric T cell acute lymphoblastic leukemia and increases its sensitivity to doxorubicin treatment. Sci Rep. 2017;7:14767 pubmed publisher
Ayoub N, Al Shami K, Alqudah M, Mhaidat N. Crizotinib, a MET inhibitor, inhibits growth, migration, and invasion of breast cancer cells in vitro and synergizes with chemotherapeutic agents. Onco Targets Ther. 2017;10:4869-4883 pubmed publisher
Gallagher L, Radhi O, Abdullah M, McCluskey A, Boyd M, Chan E. Lysosomotropism depends on glucose: a chloroquine resistance mechanism. Cell Death Dis. 2017;8:e3014 pubmed publisher
Tavangar F, Sepehri H, Saghaeian Jazi M, Asadi J. Amphotericin B potentiates the anticancer activity of doxorubicin on the MCF-7 breast cancer cells. J Chem Biol. 2017;10:143-150 pubmed publisher
Beak J, Huang W, Parker J, Hicks S, Patterson C, Simpson P, et al. An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Doxorubicin Cardiotoxicity. JACC Basic Transl Sci. 2017;2:39-53 pubmed publisher
Yuan H, Tan B, Gao S. Tenovin-6 impairs autophagy by inhibiting autophagic flux. Cell Death Dis. 2017;8:e2608 pubmed publisher
Montgomery M, Chan T, Swigart P, Myagmar B, Dash R, Simpson P. An Alpha-1A Adrenergic Receptor Agonist Prevents Acute Doxorubicin Cardiomyopathy in Male Mice. PLoS ONE. 2017;12:e0168409 pubmed publisher
Thomas R, Singh A, Cowley P, Myagmar B, Montgomery M, Swigart P, et al. A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart. JACC Basic Transl Sci. 2016;1:155-167 pubmed
Thomas R, Cowley P, Singh A, Myagmar B, Swigart P, Baker A, et al. The Alpha-1A Adrenergic Receptor in the Rabbit Heart. PLoS ONE. 2016;11:e0155238 pubmed publisher
Aho J, Helenius M, Vattulainen Collanus S, Alastalo T, Koskenvuo J. Extracellular ATP protects endothelial cells against DNA damage. Purinergic Signal. 2016;12:575-81 pubmed publisher
Bussey K, Bapat A, Linnehan C, Wandoloski M, Dastrup E, Rogers E, et al. Targeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma. Clin Transl Med. 2016;5:1 pubmed publisher
Hayano M, Yang W, Corn C, Pagano N, Stockwell B. Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation. Cell Death Differ. 2016;23:270-8 pubmed publisher
Zhitomirsky B, Assaraf Y. Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance. Oncotarget. 2015;6:1143-56 pubmed
Smyth T, Kullberg M, Malik N, Smith Jones P, Graner M, Anchordoquy T. Biodistribution and delivery efficiency of unmodified tumor-derived exosomes. J Control Release. 2015;199:145-55 pubmed publisher
Sundaresan V, Menon J, Rahimi M, Nguyen K, Wadajkar A. Dual-responsive polymer-coated iron oxide nanoparticles for drug delivery and imaging applications. Int J Pharm. 2014;466:1-7 pubmed publisher
Robinson T, Liu J, Vizeacoumar F, Sun T, MacLean N, Egan S, et al. RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. PLoS ONE. 2013;8:e78641 pubmed publisher
Gharanei M, Hussain A, Janneh O, Maddock H. Attenuation of doxorubicin-induced cardiotoxicity by mdivi-1: a mitochondrial division/mitophagy inhibitor. PLoS ONE. 2013;8:e77713 pubmed publisher
Gligorich K, Vaden R, Shelton D, Wang G, Matsen C, Looper R, et al. Development of a screen to identify selective small molecules active against patient-derived metastatic and chemoresistant breast cancer cells. Breast Cancer Res. 2013;15:R58 pubmed
Toldo S, Goehe R, Lotrionte M, Mezzaroma E, Sumner E, Biondi Zoccai G, et al. Comparative cardiac toxicity of anthracyclines in vitro and in vivo in the mouse. PLoS ONE. 2013;8:e58421 pubmed publisher
Natrajan R, Mackay A, Wilkerson P, Lambros M, Wetterskog D, Arnedos M, et al. Functional characterization of the 19q12 amplicon in grade III breast cancers. Breast Cancer Res. 2012;14:R53 pubmed
Lim Y, Park T, Lim I. B cell translocation gene 2 enhances susceptibility of HeLa cells to doxorubicin-induced oxidative damage. J Biol Chem. 2008;283:33110-8 pubmed publisher
product information
brand :
Tocris
master code :
2252
SKU :
2252/10
product name :
Doxorubicin hydrochloride
description :
Antitumor antibiotic agent. Inhibits DNA topoisomerase II
target :
DNA Topoisomerase Inhibitors
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
579.99
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Antitumor antibiotic agent that inhibits DNA topoisomerase II. DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis. Reduces intracellular tau levels.
catalog number base :
2252
product keywords :
Antitumor antibiotics agent inhibitors inhibits DNA topoisomerase II Isomerases NSC123127 chemotherapeutics Adriamycin NSC 123127 DNA Topoisomerase Apoptosis Inducers Antibiotics 2252,
extended description :
Antitumor antibiotic agent. Inhibits DNA topoisomerase II
chemical name text :
10-[(3-Amino-2,3,6-trideoxy- -L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedione hydrochloride
formula :
C 27 H 29 NO 11 .HCl
formula text :
C27H29NO11.HCl
cas num :
25316-40-9
2020 USD :
157
2021 USD :
162 USD
alt names :
Adriamycin, NSC 123127
storage :
Desiccate at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK