product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Cisplatin
catalog :
2251/50
quantity :
50 mg
price :
127 USD
more info or order :
citations: 26
Reference |
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Kathawala R, Wei L, Anreddy N, Chen K, Patel A, Alqahtani S, et al. The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study. Oncotarget. 2015;6:510-21 pubmed
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Guindon J, LAI Y, Takacs S, Bradshaw H, Hohmann A. Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics follow. Pharmacol Res. 2013;67:94-109 pubmed publisher
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Deng L, Guindon J, Vemuri V, Thakur G, White F, Makriyannis A, et al. The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB? receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy. Mol Pain. 2012;8:71 pubmed publisher
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Natrajan R, Mackay A, Wilkerson P, Lambros M, Wetterskog D, Arnedos M, et al. Functional characterization of the 19q12 amplicon in grade III breast cancers. Breast Cancer Res. 2012;14:R53 pubmed
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Ibáñez G, Shum D, Blum G, Bhinder B, Radu C, Antczak C, et al. A high throughput scintillation proximity imaging assay for protein methyltransferases. Comb Chem High Throughput Screen. 2012;15:359-71 pubmed
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product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2251
SKU :
2251/50
product name :
Cisplatin
description :
Potent pro-apoptotic anticancer agent; activates caspase-3
target :
Caspase Activators
unit size :
50 mg
category :
Small Molecules
storage :
Store at RT
observed molecular weight :
300.05
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Cisplatin is a potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF- -induced apoptosis.
product keywords :
Potent proapoptotic anticancer agent activates caspase-3 DNA-alkylating antitumor Caspases Apoptosis Inducers Proteinases Proteases chemotherapeutics CDDP Caspases Apoptosis Inducers 2251,
extended description :
Potent pro-apoptotic anticancer agent; activates caspase-3
chemical name text :
cis-Diaminodichloroplatinum
formula :
Cl2H6N2Pt
formula text :
Cl2H6N2Pt
cas num :
15663-27-1
USD :
121
USD 2025 :
127 USD
product details :
Potent pro-apoptotic anticancer agent; activates caspase-3
alt names :
CDDP
more info or order :
company information

Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com800-343-7475
headquarters: UK
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