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company name :
Tocris Bioscience
product type :
chemical
product name :
Cisplatin
catalog :
2251/50
quantity :
50 mg
price :
127 USD
more info or order :
citations: 26
Reference
Xiao W, Wang L, Howard J, Kolhe R, Rojiani A, Rojiani M. TIMP-1-Mediated Chemoresistance via Induction of IL-6 in NSCLC. Cancers (Basel). 2019;11: pubmed publisher
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Brown J, Yonekubo Y, Hanson N, Sastre Perona A, Basin A, Rytlewski J, et al. TGF-β-Induced Quiescence Mediates Chemoresistance of Tumor-Propagating Cells in Squamous Cell Carcinoma. Cell Stem Cell. 2017;21:650-664.e8 pubmed publisher
Chia S, Low J, Zhang X, Kwang X, Chong F, Sharma A, et al. Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time. Nat Commun. 2017;8:435 pubmed publisher
Zhang H, Patel A, Wang Y, Zhang Y, Kathawala R, Qiu L, et al. The BTK Inhibitor Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1- and ABCC10-Overexpressing Cells and Tumors. Mol Cancer Ther. 2017;16:1021-1030 pubmed publisher
Florea A, Varghese E, McCallum J, Mahgoub S, Helmy I, Varghese S, et al. Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma. Oncotarget. 2017;8:22876-22893 pubmed publisher
Deng L, Ng L, Ozawa T, Stella N. Quantitative Analyses of Synergistic Responses between Cannabidiol and DNA-Damaging Agents on the Proliferation and Viability of Glioblastoma and Neural Progenitor Cells in Culture. J Pharmacol Exp Ther. 2017;360:215-224 pubmed publisher
Fedoseienko A, Wieringa H, Wisman G, Duiker E, Reyners A, Hofker M, et al. Nuclear COMMD1 Is Associated with Cisplatin Sensitivity in Ovarian Cancer. PLoS ONE. 2016;11:e0165385 pubmed publisher
Kim M, Caplen N, Chakka S, Hernandez L, House C, Pongas G, et al. Identification of therapeutic targets applicable to clinical strategies in ovarian cancer. BMC Cancer. 2016;16:678 pubmed publisher
Patmanathan S, Johnson S, Lai S, Panja Bernam S, Lopes V, Wei W, et al. Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2. Sci Rep. 2016;6:25650 pubmed publisher
Sun R, Jiang B, Qi H, Zhang X, Yang J, Duan J, et al. SOX4 contributes to the progression of cervical cancer and the resistance to the chemotherapeutic drug through ABCG2. Cell Death Dis. 2015;6:e1990 pubmed publisher
Lin H, Heo B, Yoon M. A New Rat Model of Cisplatin-induced Neuropathic Pain. Korean J Pain. 2015;28:236-43 pubmed publisher
Saja M, Baudino L, Jackson W, Cook H, Malik T, Fossati Jimack L, et al. Triglyceride-Rich Lipoproteins Modulate the Distribution and Extravasation of Ly6C/Gr1(low) Monocytes. Cell Rep. 2015;12:1802-15 pubmed publisher
Marcus D, Zee M, Hughes A, Yuill M, Hohmann A, Mackie K, et al. Tolerance to the antinociceptive effects of chronic morphine requires c-Jun N-terminal kinase. Mol Pain. 2015;11:34 pubmed publisher
Kathawala R, Wei L, Anreddy N, Chen K, Patel A, Alqahtani S, et al. The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study. Oncotarget. 2015;6:510-21 pubmed
Liu Y, Kwiatkowski D. Combined CDKN1A/TP53 mutation in bladder cancer is a therapeutic target. Mol Cancer Ther. 2015;14:174-82 pubmed publisher
Guindon J, Deng L, Fan B, Wager Miller J, Hohmann A. Optimization of a cisplatin model of chemotherapy-induced peripheral neuropathy in mice: use of vitamin C and sodium bicarbonate pretreatments to reduce nephrotoxicity and improve animal health status. Mol Pain. 2014;10:56 pubmed publisher
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product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2251
SKU :
2251/50
product name :
Cisplatin
description :
Potent pro-apoptotic anticancer agent; activates caspase-3
target :
Caspase Activators
unit size :
50 mg
category :
Small Molecules
storage :
Store at RT
observed molecular weight :
300.05
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Cisplatin is a potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF- -induced apoptosis.
product keywords :
Potent proapoptotic anticancer agent activates caspase-3 DNA-alkylating antitumor Caspases Apoptosis Inducers Proteinases Proteases chemotherapeutics CDDP Caspases Apoptosis Inducers 2251,
extended description :
Potent pro-apoptotic anticancer agent; activates caspase-3
chemical name text :
cis-Diaminodichloroplatinum
formula :
Cl2H6N2Pt
formula text :
Cl2H6N2Pt
cas num :
15663-27-1
USD :
121
USD 2025 :
127 USD
product details :
Potent pro-apoptotic anticancer agent; activates caspase-3
alt names :
CDDP
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK