SL 0101-1 | Tocris Bioscience 2250/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SL 0101-1

catalog :

2250/1

quantity :

1 mg

price :

394 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Al Ejeh F, Miranda M, Shi W, Simpson P, Song S, Vargas A, et al. Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer. Oncotarget. 2014;5:3145-58 pubmed
Gawecka J, Young Robbins S, Sulzmaier F, Caliva M, Heikkila M, Matter M, et al. RSK2 protein suppresses integrin activation and fibronectin matrix assembly and promotes cell migration. J Biol Chem. 2012;287:43424-37 pubmed publisher
Li R, Chen D, Zhou R, Jia S, Yang J, Clegg J, et al. Involvement of polo-like kinase 1 (Plk1) in mitotic arrest by inhibition of mitogen-activated protein kinase-extracellular signal-regulated kinase-ribosomal S6 kinase 1 (MEK-ERK-RSK1) cascade. J Biol Chem. 2012;287:15923-34 pubmed publisher
Gawecka J, Geerts D, Koster J, Caliva M, Sulzmaier F, Opoku Ansah J, et al. PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma. Int J Cancer. 2012;131:1556-68 pubmed publisher
Meitzen J, Luoma J, Stern C, Mermelstein P. ?1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem. 2011;116:984-95 pubmed publisher
Kroczynska B, Joshi S, Eklund E, Verma A, Kotenko S, Fish E, et al. Regulatory effects of ribosomal S6 kinase 1 (RSK1) in IFN? signaling. J Biol Chem. 2011;286:1147-56 pubmed publisher
Roselli F, Hutzler P, Wegerich Y, Livrea P, Almeida O. Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways. PLoS ONE. 2009;4:e6011 pubmed publisher

product information

brand :

Tocris

catalog number base :

2250

SKU :

2250/1

product name :

SL 0101-1

units size :

1 mg

description :

Selective ribosomal S6 kinase (RSK) inhibitor

target :

RSK Inhibitors

category :

Small Molecules

purity :

95%

observed molecular weight :

516.46

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SL 0101-1 is a selective inhibitor of ribosomal S6 kinase (RSK) (IC50 = 89 nM for RSK2). Does not inhibit upstream kinases such as MEK, Raf and PKC. Inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line.

top caption :

Selective ribosomal S6 kinase (RSK) inhibitor

extended description :

Selective ribosomal S6 kinase (RSK) inhibitor

chemical name text :

3-[(3,4-Di-O-acetyl-6-deoxy- -L-mannopyranosyl)oxy]-5,7-dihydro-2-(4-hydroxyphenyl)-4H-1benzopyran-4-one

formula :

C25H24O12

formula text :

C25H24O12

cas num :

77307-50-7

USD :

394 USD

product details :

Selective ribosomal S6 kinase (RSK) inhibitor

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage