GW 441756 | Tocris Bioscience 2238 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GW 441756

catalog :

2238

quantity :

10 mg (also 50 mg)

price :

221 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Donatien P, Anand U, Yiangou Y, Sinisi M, Fox M, MacQuillan A, et al. Granulocyte-macrophage colony-stimulating factor receptor expression in clinical pain disorder tissues and role in neuronal sensitization. Pain Rep. 2018;3:e676 pubmed publisher
Rees M, Seashore Ludlow B, Cheah J, Adams D, Price E, Gill S, et al. Correlating chemical sensitivity and basal gene expression reveals mechanism of action. Nat Chem Biol. 2016;12:109-16 pubmed publisher
Lawn S, Krishna N, Pisklakova A, Qu X, Fenstermacher D, Fournier M, et al. Neurotrophin signaling via TrkB and TrkC receptors promotes the growth of brain tumor-initiating cells. J Biol Chem. 2015;290:3814-24 pubmed publisher
Edwards L, Woolard K, Son M, Li A, Lee J, Ene C, et al. Effect of brain- and tumor-derived connective tissue growth factor on glioma invasion. J Natl Cancer Inst. 2011;103:1162-78 pubmed publisher
Wang J, Hancock M, Dudek J, Bi K. Cellular assays for high-throughput screening for modulators of Trk receptor tyrosine kinases. Curr Chem Genomics. 2008;1:27-33 pubmed publisher

product information

brand :

Tocris

master code :

2238

SKU :

2238/10

product name :

GW 441756

description :

Potent, selective TrkA inhibitor

target :

Trk Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

275.31

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC50 = 2 nM). Displays 100-fold selectivity over a range of other kinases.

catalog number base :

2238

product keywords :

Potent selective TrkA inhibitors inhibits Neurotrophin Receptors Receptor Tyrosine Kinases RTKs GW441756 GlaxoSmithKline GSK Trk Receptors 2238,

extended description :

Potent, selective TrkA inhibitor

chemical name text :

1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one

formula :

C 17 H 13 N 3 O

formula text :

C17H13N3O

cas num :

504433-23-2

2020 USD :

214

2021 USD :

221 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage