GW 441756 | Tocris Bioscience 2238/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GW 441756

catalog :

2238/10

quantity :

10 mg (also 50 mg)

price :

278 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Donatien P, Anand U, Yiangou Y, Sinisi M, Fox M, MacQuillan A, et al. Granulocyte-macrophage colony-stimulating factor receptor expression in clinical pain disorder tissues and role in neuronal sensitization. Pain Rep. 2018;3:e676 pubmed publisher
Alam M, Choi S, Lee D. Synthesis, anticancer, and docking studies of salicyl-hydrazone analogues: A novel series of small potent tropomyosin receptor kinase A inhibitors. Bioorg Med Chem. 2017;25:389-396 pubmed publisher
Rees M, Seashore Ludlow B, Cheah J, Adams D, Price E, Gill S, et al. Correlating chemical sensitivity and basal gene expression reveals mechanism of action. Nat Chem Biol. 2016;12:109-16 pubmed publisher
Landowski L, Pavez M, Brown L, Gasperini R, Taylor B, West A, et al. Low-density Lipoprotein Receptor-related Proteins in a Novel Mechanism of Axon Guidance and Peripheral Nerve Regeneration. J Biol Chem. 2016;291:1092-102 pubmed publisher
Lawn S, Krishna N, Pisklakova A, Qu X, Fenstermacher D, Fournier M, et al. Neurotrophin signaling via TrkB and TrkC receptors promotes the growth of brain tumor-initiating cells. J Biol Chem. 2015;290:3814-24 pubmed publisher
Edwards L, Woolard K, Son M, Li A, Lee J, Ene C, et al. Effect of brain- and tumor-derived connective tissue growth factor on glioma invasion. J Natl Cancer Inst. 2011;103:1162-78 pubmed publisher
Wang J, Hancock M, Dudek J, Bi K. Cellular assays for high-throughput screening for modulators of Trk receptor tyrosine kinases. Curr Chem Genomics. 2008;1:27-33 pubmed publisher

image

image 1 :

Cat.No. 2238 - GW 441756 C17H13N3O CAS No. 504433-23-2

product information

brand :

Tocris

catalog number base :

2238

SKU :

2238/10

product name :

GW 441756

units size :

10 mg (also 50 mg)

description :

Potent, selective TrkA inhibitor

target :

Trk Receptor Inhibitors

category :

Small Molecules

purity :

99%

observed molecular weight :

275.31

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GW 441756 is a potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC50 = 2 nM). Displays 100-fold selectivity over a range of other kinases.

top caption :

Potent, selective TrkA inhibitor

extended description :

Potent, selective TrkA inhibitor

chemical name text :

1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one

formula :

C17H13N3O

formula text :

C17H13N3O

cas num :

504433-23-2

USD :

278 USD

product details :

Potent, selective TrkA inhibitor

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage