GW 0742 | Tocris Bioscience 2229/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GW 0742

catalog :

2229/10

quantity :

10 mg (also 50 mg)

price :

292 USD

more info or order :

Tocris Bioscience product webpage

citations: 14

Reference
Smith D, Martinelli R, Besra G, Illarionov P, Szatmari I, Brazda P, et al. Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties. Psychopharmacology (Berl). 2019;: pubmed publisher
Martin Martin N, Zabala Letona A, Fernandez Ruiz S, Arreal L, Camacho L, Castillo Martin M, et al. PPARδ Elicits Ligand-Independent Repression of Trefoil Factor Family to Limit Prostate Cancer Growth. Cancer Res. 2018;78:399-409 pubmed publisher
Halstead A, Kapadia C, Bolzenius J, Chu C, Schriefer A, Wartman L, et al. Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation. elife. 2017;6: pubmed publisher
Wang B, Fu X, Zhu M, Du M. Retinoic acid inhibits white adipogenesis by disrupting GADD45A-mediated Zfp423 DNA demethylation. J Mol Cell Biol. 2017;9:338-349 pubmed publisher
Zhang Z, Duan Y, Wu Z, Zhang H, Ren J, Huang L. PPARD is an Inhibitor of Cartilage Growth in External Ears. Int J Biol Sci. 2017;13:669-681 pubmed publisher
Qian G, Fan W, Ahlemeyer B, Karnati S, Baumgart Vogt E. Peroxisomes in Different Skeletal Cell Types during Intramembranous and Endochondral Ossification and Their Regulation during Osteoblast Differentiation by Distinct Peroxisome Proliferator-Activated Receptors. PLoS ONE. 2015;10:e0143439 pubmed publisher
Niu H, Ku P, Niu C, Cheng J, Lee K. Development of PPAR-agonist GW0742 as antidiabetic drug: study in animals. Drug Des Devel Ther. 2015;9:5625-32 pubmed publisher
Teske K, Nandhikonda P, Bogart J, Feleke B, Sidhu P, Yuan N, et al. Modulation of Transcription mediated by the Vitamin D Receptor and the Peroxisome Proliferator-Activated Receptor Î´ in the presence of GW0742 analogs. J Biomol Res Ther. 2014;3: pubmed
PÃ©rez Schindler J, Svensson K, Vargas FernÃ¡ndez E, Santos G, Wahli W, Handschin C. The coactivator PGC-1Î± regulates skeletal muscle oxidative metabolism independently of the nuclear receptor PPARÎ²/Î´ in sedentary mice fed a regular chow diet. Diabetologia. 2014;57:2405-12 pubmed publisher
Tsai C, Lee K, Chen S, Chen L, Liu K, Cheng J. Decrease of PPARδ in Type-1-Like Diabetic Rat for Higher Mortality after Spinal Cord Injury. PPAR Res. 2014;2014:456386 pubmed publisher
Capozzi M, McCollum G, Savage S, Penn J. Peroxisome proliferator-activated receptor-?/? regulates angiogenic cell behaviors and oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2013;54:4197-207 pubmed publisher
Tian X, Wong W, Wang N, Lu Y, Cheang W, Liu J, et al. PPAR? activation protects endothelial function in diabetic mice. Diabetes. 2012;61:3285-93 pubmed publisher
Batista F, Trivella D, Bernardes A, Gratieri J, Oliveira P, Figueira A, et al. Structural insights into human peroxisome proliferator activated receptor delta (PPAR-delta) selective ligand binding. PLoS ONE. 2012;7:e33643 pubmed publisher
Hatano Y, Man M, Uchida Y, Crumrine D, Mauro T, Feingold K, et al. Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators. J Allergy Clin Immunol. 2010;125:160-9.e1-5 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2229

SKU :

2229/10

product name :

GW 0742

description :

Highly selective, potent PPAR agonist

target :

PPAR delta Receptor Agonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Desiccate at +4°C

observed molecular weight :

471.49

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GW 0742 is a potent and highly selective PPAR agonist. EC50 values are 0.001, 1.1 and 2 u M for transactivation of human PPAR , - , and - receptors respectively. Neuroprotective in rat cerebellar granule neuronal cultures after brief (12-hour) exposure but exhibits inherent toxicity after prolonged (48-hour) incubation. Increases rate of fatty acid oxidation and protects against ischemia/reperfusion injury in neonatal and adult cardiomyocytes.

product keywords :

selective potent PPAR PPARdelta agonists Peroxisome Proliferator-activating Receptors GW0742 GlaxoSmithKline GSK PPARdelta Receptors 2229,

extended description :

Highly selective, potent PPAR agonist

chemical name text :

[4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]acetic acid

formula :

C21H17F4NO3S2

formula text :

C21H17F4NO3S2

cas num :

317318-84-6

USD :

283

USD 2025 :

292 USD

product details :

Highly selective, potent PPAR agonist

more info or order :

Tocris Bioscience product webpage