CGP 71683 hydrochloride | Tocris Bioscience 2199/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CGP 71683 hydrochloride

catalog :

2199/10

quantity :

10 mg (also 50 mg)

price :

287 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Czarnecka M, Trinh E, Lu C, Kuan Celarier A, Galli S, Hong S, et al. Neuropeptide Y receptor Y5 as an inducible pro-survival factor in neuroblastoma: implications for tumor chemoresistance. Oncogene. 2015;34:3131-43 pubmed publisher
Tilan J, Lu C, Galli S, Izycka Swieszewska E, Earnest J, Shabbir A, et al. Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects. Oncotarget. 2013;4:2487-501 pubmed
REIDELBERGER R, Haver A, Chelikani P. Role of peptide YY(3-36) in the satiety produced by gastric delivery of macronutrients in rats. Am J Physiol Endocrinol Metab. 2013;304:E944-50 pubmed publisher
Atasoy D, Betley J, Su H, Sternson S. Deconstruction of a neural circuit for hunger. Nature. 2012;488:172-7 pubmed publisher
Han R, Kitlinska J, Munday W, Gallicano G, Zukowska Z. Stress hormone epinephrine enhances adipogenesis in murine embryonic stem cells by up-regulating the neuropeptide Y system. PLoS ONE. 2012;7:e36609 pubmed publisher
Lu C, Tilan J, Everhart L, Czarnecka M, Soldin S, Mendu D, et al. Dipeptidyl peptidases as survival factors in Ewing sarcoma family of tumors: implications for tumor biology and therapy. J Biol Chem. 2011;286:27494-505 pubmed publisher
Demorrow S, Onori P, Venter J, Invernizzi P, Frampton G, White M, et al. Neuropeptide Y inhibits cholangiocarcinoma cell growth and invasion. Am J Physiol Cell Physiol. 2011;300:C1078-89 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2199

SKU :

2199/10

product name :

CGP 71683 hydrochloride

description :

Highly selective and potent non-peptide NPY Y5 receptor antagonist

target :

NPY Receptor Antagonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

512.07

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CGP 71683 hydrochloride is an extremely selective, non-peptide NPY Y5 receptor antagonist. Displays 1000-fold selectivity over Y1, Y2 and Y4 receptors; IC50 values are 1.4, 2765, 7187 and 5637 nM at cloned rat Y5, Y1, Y2 and Y4 receptors respectively. Potently inhibits NPY-induced food intake following i.p. administration in diabetic, free-feeding and fasted rats.

product keywords :

selective potent non-peptide NPY Y5 receptor antagonists Neuropeptide Y Receptors CGP71683 hydrochloride neuropeptides NPY Receptors 2199,

extended description :

Highly selective and potent non-peptide NPY Y5 receptor antagonist

chemical name text :

N-[[trans-4-[[(4-Amino-2-quinazolinyl)amino]methyl]cyclohexyl]methyl]-1-naphthalenesulfonamide hydrochloride

formula :

C26H29N5O2S.HCl

formula text :

C26H29N5O2S.HCl

cas num :

192322-50-2

USD :

278

USD 2025 :

287 USD

product details :

Highly selective and potent non-peptide NPY Y5 receptor antagonist

more info or order :

Tocris Bioscience product webpage