Mibefradil dihydrochloride | Tocris Bioscience 2198/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Mibefradil dihydrochloride

catalog :

2198/10

quantity :

10 mg (also 50 mg)

price :

296 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Weber L, Al Refae K, Ebbert J, Jagers P, Altmuller J, Becker C, et al. Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis. PLoS ONE. 2017;12:e0172491 pubmed publisher
Prigge C, Yeh P, Liou N, Lee C, You S, Liu L, et al. M1 ipRGCs Influence Visual Function through Retrograde Signaling in the Retina. J Neurosci. 2016;36:7184-97 pubmed publisher
BraganÃ§a B, Oliveira Monteiro N, Ferreirinha F, Lima P, Faria M, Fontes Sousa A, et al. Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria. Front Pharmacol. 2016;7:45 pubmed publisher
Wang X, Tian B, Huang Y, Peng X, Chen L, Li J, et al. Hydrogen sulfide-induced itch requires activation of Cav3.2 T-type calcium channel in mice. Sci Rep. 2015;5:16768 pubmed publisher
Cilz N, Kurada L, Hu B, Lei S. Dopaminergic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K⁺, and T-type Ca²⁺ channels. Cereb Cortex. 2014;24:3195-208 pubmed publisher
Stone A, Kim J, Yamauchi K, Ruiz Velasco V, Kaufman M. Attenuation of autonomic reflexes by A803467 may not be solely caused by blockade of NaV 1.8 channels. Neurosci Lett. 2013;543:177-82 pubmed publisher
Weick M, Demb J. Delayed-rectifier K channels contribute to contrast adaptation in mammalian retinal ganglion cells. Neuron. 2011;71:166-79 pubmed publisher
Higley M, Sabatini B. Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors. Nat Neurosci. 2010;13:958-66 pubmed publisher
Grubb M, Burrone J. Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability. Nature. 2010;465:1070-4 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2198

SKU :

2198/10

product name :

Mibefradil dihydrochloride

description :

CaV3.x blocker

target :

Cav3.x Channel Blockers

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

97%

storage :

Store at -20°C

observed molecular weight :

568.56

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Mibefradil dihydrochloride is a Ca2+ channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50 values of 2.7 u M and 18.6 u M for T-type and L-type channels respectively. Antihypertensive agent.

product keywords :

Ca2+ channel blockers T-type Calcium CaV Channels L-Type P-Type R-Type Q-Type T-Type N-Type voltage-gated voltage-dependent Ro405967 Ro 40-5967 Cav3.x Channels 2198, Voltage-gated calcium channel blocker, voltage gated calcium channel, high-voltage activated Ca2+ channel, high voltage gated ca2+ channel

extended description :

CaV3.x blocker

chemical name text :

(1S,2S)-2-[2-[[3-(1H-Benzimidazol-2yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl methoxyacetoacetate dihydrochloride

formula :

C29H38FN3O3.2HCl

formula text :

C29H38FN3O3.2HCl

cas num :

116666-63-8

USD :

284

USD 2025 :

296 USD

product details :

CaV3.x blocker

alt names :

Ro 40-5967

more info or order :

Tocris Bioscience product webpage