product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Mibefradil dihydrochloride
catalog :
2198/10
quantity :
10 mg (also 50 mg)
price :
296 USD
more info or order :
citations: 9
Reference
Weber L, Al Refae K, Ebbert J, Jagers P, Altmuller J, Becker C, et al. Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis. PLoS ONE. 2017;12:e0172491 pubmed publisher
Prigge C, Yeh P, Liou N, Lee C, You S, Liu L, et al. M1 ipRGCs Influence Visual Function through Retrograde Signaling in the Retina. J Neurosci. 2016;36:7184-97 pubmed publisher
Bragança B, Oliveira Monteiro N, Ferreirinha F, Lima P, Faria M, Fontes Sousa A, et al. Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria. Front Pharmacol. 2016;7:45 pubmed publisher
Wang X, Tian B, Huang Y, Peng X, Chen L, Li J, et al. Hydrogen sulfide-induced itch requires activation of Cav3.2 T-type calcium channel in mice. Sci Rep. 2015;5:16768 pubmed publisher
Cilz N, Kurada L, Hu B, Lei S. Dopaminergic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K⁺, and T-type Ca²⁺ channels. Cereb Cortex. 2014;24:3195-208 pubmed publisher
Stone A, Kim J, Yamauchi K, Ruiz Velasco V, Kaufman M. Attenuation of autonomic reflexes by A803467 may not be solely caused by blockade of NaV 1.8 channels. Neurosci Lett. 2013;543:177-82 pubmed publisher
Weick M, Demb J. Delayed-rectifier K channels contribute to contrast adaptation in mammalian retinal ganglion cells. Neuron. 2011;71:166-79 pubmed publisher
Higley M, Sabatini B. Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors. Nat Neurosci. 2010;13:958-66 pubmed publisher
Grubb M, Burrone J. Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability. Nature. 2010;465:1070-4 pubmed publisher
product information
brand :
Tocris
catalog number base :
2198
SKU :
2198/10
product name :
Mibefradil dihydrochloride
units size :
10 mg (also 50 mg)
description :
CaV3.x blocker
target :
Cav3.x Channel Blockers
category :
Small Molecules
purity :
97%
observed molecular weight :
568.56
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
review stars :
5
details of functionality :
Mibefradil dihydrochloride is a Ca2+ channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50 values of 2.7 u M and 18.6 u M for T-type and L-type channels respectively. Antihypertensive agent.
top caption :
CaV3.x blocker
extended description :
CaV3.x blocker
chemical name text :
(1S,2S)-2-[2-[[3-(1H-Benzimidazol-2yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl methoxyacetoacetate dihydrochloride
formula :
C29H38FN3O3.2HCl
formula text :
C29H38FN3O3.2HCl
cas num :
116666-63-8
USD :
296 USD
product details :
CaV3.x blocker
alt names :
Ro 40-5967
storage :
Store at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK