L-755,507 | Tocris Bioscience 2197/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

L-755,507

catalog :

2197/10

quantity :

10 mg (also 50 mg)

price :

238 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Riesenberg S, Maricic T. Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells. Nat Commun. 2018;9:2164 pubmed publisher
Kornete M, Marone R, Jeker L. Highly Efficient and Versatile Plasmid-Based Gene Editing in Primary T Cells. J Immunol. 2018;200:2489-2501 pubmed publisher
Sin Y, Price P, Ballantyne L, Funk C. Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency. Sci Rep. 2017;7:2585 pubmed publisher
Pinder J, Salsman J, Dellaire G. Nuclear domain 'knock-in' screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing. Nucleic Acids Res. 2015;43:9379-92 pubmed publisher
Afeli S, Hristov K, Petkov G. Do β3-adrenergic receptors play a role in guinea pig detrusor smooth muscle excitability and contractility?. Am J Physiol Renal Physiol. 2012;302:F251-63 pubmed publisher
Coan K, Maltby D, Burlingame A, Shoichet B. Promiscuous aggregate-based inhibitors promote enzyme unfolding. J Med Chem. 2009;52:2067-75 pubmed publisher
Coan K, Shoichet B. Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors. J Am Chem Soc. 2008;130:9606-12 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2197

SKU :

2197/10

product name :

L-755,507

description :

Very potent and selective 3 partial agonist

target :

Adrenergic beta-3 Receptor Agonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

584.73

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

L-755,507 is a potent 3-adrenergic receptor partial agonist 1000-fold selective over 1- and 2-adrenoceptors (EC50 values are 0.43, 580 and 10000 nM for activation of cloned human 3-, 1- and 2-adrenoceptors respectively). Stimulates lipolysis in rhesus adipocytes in vitro (EC50 = 3.9 nM). Enhances CRISPR-mediated homology-directed repair (HDR) efficiency 2-3-fold for large fragments and ~9-fold for point mutations, in human induced pluripotent stem cells (iPSCs).

product keywords :

potent selective 3 beta3 partial agonists adrenergic receptors adrenoceptors L755507 CRISPR Cas9 HDR NHEJ homology directed repair nonhomologous end joining hematopoietic haematopoietic stem cells HSC Adrenergic Beta-3 Receptors CRISPR Reagents Hematopoietic Stem Cells 2197,

extended description :

Very potent and selective 3 partial agonist

chemical name text :

4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-benzenesulfonamide

formula :

C30H40N4O6S

formula text :

C30H40N4O6S

cas num :

159182-43-1

USD :

235

USD 2025 :

238 USD

product details :

Very potent and selective 3 partial agonist

more info or order :

Tocris Bioscience product webpage