Eliprodil | Tocris Bioscience 2195 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Eliprodil

catalog :

2195

quantity :

10 mg (also 50 mg)

price :

112 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Rennekamp A, Huang X, Wang Y, Patel S, Lorello P, Cade L, et al. ?1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol. 2016;12:552-8 pubmed publisher
Hedegaard M, Hansen K, Andersen K, Brauner Osborne H, Traynelis S. Molecular pharmacology of human NMDA receptors. Neurochem Int. 2012;61:601-9 pubmed publisher

product information

brand :

Tocris

master code :

2195

SKU :

2195/10

product name :

Eliprodil

description :

Non-competitive and GluN2B-selective NMDA antagonist

target :

NMDA Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

347.86

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Non-competitive NMDA receptor antagonist that acts at the polyamine modulatory site. Selective for GluN2B (formally NR2B)- over GluN2A (NR2A)- and GluN2C (NR2C)-containing receptors (IC50 values are 1, 100 and 100 u M respectively). Also 1 ligand (Ki = 0.013 u M). Antagonizes neuronal voltage-gated Ca2+ channels and selectively inhibits the rapid component of the delayed rectifier K+ current (IKr). Neuroprotective. . Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions .

catalog number base :

2195

product keywords :

sigma ligands 1 sigma1 2 sigma2 polyamine site NMDA antagonists Ca2+ channel blockers Neuroprotective Non-competitive NR2B-selective Receptors Glutamate N-Methyl-D-Aspartate iGluR Ionotropic GluN2B NMDA Receptors Sigma1 Receptors 2195,

extended description :

Non-competitive and GluN2B-selective NMDA antagonist

chemical name text :

-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol

formula :

C 20 H 23 ClFNO

formula text :

C20H23ClFNO

cas num :

119431-25-3

2020 USD :

112

2021 USD :

112 USD

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage