S-Trityl-L-cysteine | Tocris Bioscience 2191/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

S-Trityl-L-cysteine

catalog :

2191/50

quantity :

50 mg

price :

134 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Cilibrasi C, Guzzi A, Bazzoni R, Riva G, Cadamuro M, Hochegger H, et al. A Ploidy Increase Promotes Sensitivity of Glioma Stem Cells to Aurora Kinases Inhibition. J Oncol. 2019;2019:9014045 pubmed publisher
Ferreira L, Figueiredo A, Orr B, Lopes D, Maiato H. Dissecting the role of the tubulin code in mitosis. Methods Cell Biol. 2018;144:33-74 pubmed publisher
Hindriksen S, Bramer A, Truong M, Vromans M, Post J, Verlaan Klink I, et al. Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells. PLoS ONE. 2017;12:e0179514 pubmed publisher
Hengeveld R, Vromans M, Vleugel M, Hadders M, Lens S. Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing. Nat Commun. 2017;8:15542 pubmed publisher
Olson O, Kim H, Quail D, Foley E, Joyce J. Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents. Cell Rep. 2017;19:101-113 pubmed publisher
MÃ¼llers E, Silva Cascales H, Jaiswal H, Saurin A, Lindqvist A. Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase. Cell Cycle. 2014;13:2733-43 pubmed publisher
Hegarat N, Vesely C, Vinod P, Ocasio C, Peter N, Gannon J, et al. PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit. PLoS Genet. 2014;10:e1004004 pubmed publisher
van der Waal M, Saurin A, Vromans M, Vleugel M, Wurzenberger C, Gerlich D, et al. Mps1 promotes rapid centromere accumulation of Aurora B. EMBO Rep. 2012;13:847-54 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2191

SKU :

2191/50

product name :

S-Trityl-L-cysteine

description :

Potent, selective inhibitor of mitotic kinesin Eg5

target :

Kinesin Inhibitors

unit size :

50 mg

category :

Small Molecules

storage :

Store at +4°C

observed molecular weight :

363.47

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

S -Trityl-L-cysteine is a potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, a protein required for establishing and maintaining a bipolar spindle. Inhibits basal ATPase activity (IC50 = 1 mM) and microtubule-activated ATPase activity of Eg5 (IC50 = 140 nM). Induces mitotic arrest in HeLa cells with an IC50 of 700 nM. Displays antitumor activity.

product keywords :

Potent selective inhibitors inhibits mitotic kinesin Eg5 Mitotic Kinesin Mitosis NSC83265 NSC 83265 Kinesin Mitosis 2191,

extended description :

Potent, selective inhibitor of mitotic kinesin Eg5

chemical name text :

S-(Triphenylmethyl)-L-cysteine

formula :

C22H21NO2S

formula text :

C22H21NO2S

cas num :

7/7/99

USD :

132

USD 2025 :

134 USD

product details :

Potent, selective inhibitor of mitotic kinesin Eg5

alt names :

NSC 83265

more info or order :

Tocris Bioscience product webpage