CMPD-1 | Tocris Bioscience 2186/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CMPD-1

catalog :

2186/10

quantity :

10 mg (also 50 mg)

price :

238 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Ryals M, Morell R, Martin D, Boger E, Wu P, Raible D, et al. The Inner Ear Heat Shock Transcriptional Signature Identifies Compounds That Protect Against Aminoglycoside Ototoxicity. Front Cell Neurosci. 2018;12:445 pubmed publisher
Breindel J, Haskins J, Cowell E, Zhao M, Nguyen D, Stern D. EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis. Cancer Res. 2013;73:5053-65 pubmed publisher
Fricke J, Koo L, Brown C, Collins P. p38 and OGT sequestration into viral inclusion bodies in cells infected with human respiratory syncytial virus suppresses MK2 activities and stress granule assembly. J Virol. 2013;87:1333-47 pubmed publisher

product information

brand :

Tocris

catalog number base :

2186

SKU :

2186/10

product name :

CMPD-1

units size :

10 mg (also 50 mg)

description :

Selective inhibitor of p38 -mediated MK2a phosphorylation; also tubulin polymerization inhibitor

target :

p38 Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

349.4

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

review stars :

details of functionality :

CMPD-1 is a non-ATP-competitive, selective inhibitor of p38 -mediated MK2a (mitogen-activated protein kinase-2a) phosphorylation (apparent Ki = 330 nM). Does not inhibit p38 -mediated phosphorylation of MBP and ATF-2. Also tubulin polymerization inhibitor. Cytotoxic in glioblastoma cells at concentrations that do not affect the MK2 pathway.

top caption :

Selective inhibitor of p38 -mediated MK2a phosphorylation; also tubulin polymerization inhibitor

extended description :

Selective inhibitor of p38 -mediated MK2a phosphorylation; also tubulin polymerization inhibitor

chemical name text :

2 -Fluoro-N-(4-hydroxyphenyl)-[1,1 -biphenyl]-4-butanamide

formula :

C22H20FNO2

formula text :

C22H20FNO2

cas num :

41179-33-3

USD :

238 USD

product details :

Selective inhibitor of p38 -mediated MK2a phosphorylation; also tubulin polymerization inhibitor

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage