SN-6 | Tocris Bioscience 2184 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SN-6

catalog :

2184

quantity :

10 mg (also 50 mg)

price :

195 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Bastioli G, Piccirillo S, Castaldo P, Magi S, Tozzi A, Amoroso S, et al. Selective inhibition of mitochondrial sodium-calcium exchanger protects striatal neurons from α-synuclein plus rotenone induced toxicity. Cell Death Dis. 2019;10:80 pubmed publisher
Piccirillo S, Castaldo P, Macrì M, Amoroso S, Magi S. Glutamate as a potential "survival factor" in an in vitro model of neuronal hypoxia/reoxygenation injury: leading role of the Na+/Ca2+ exchanger. Cell Death Dis. 2018;9:731 pubmed publisher
Wang Y, Chen L, Li M, Cha H, Iwamoto T, Zhang J. Conditional knockout of smooth muscle sodium calcium exchanger type-1 lowers blood pressure and attenuates Angiotensin II-salt hypertension. Physiol Rep. 2015;3: pubmed publisher
Ciapa B, Philippe L. Intracellular and extracellular pH and Ca are bound to control mitosis in the early sea urchin embryo via ERK and MPF activities. PLoS ONE. 2013;8:e66113 pubmed publisher
Wang F, Smith N, Xu Q, Fujita T, Baba A, Matsuda T, et al. Astrocytes modulate neural network activity by Ca²+-dependent uptake of extracellular K+. Sci Signal. 2012;5:ra26 pubmed publisher
Fu L, van den Pol A. Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism. J Neurosci. 2010;30:10205-19 pubmed publisher
Barrientos G, Bose D, Feng W, Padilla I, Pessah I. The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate (KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channels. Mol Pharmacol. 2009;76:560-8 pubmed publisher
Pezier A, Bobkov Y, Ache B. The Na+/Ca2+ exchanger inhibitor, KB-R7943, blocks a nonselective cation channel implicated in chemosensory transduction. J Neurophysiol. 2009;101:1151-9 pubmed publisher

product information

brand :

Tocris

master code :

2184

SKU :

2184/10

product name :

SN-6

description :

Selective Na+/Ca2+ exchange inhibitor (reverse mode)

target :

Na+/Ca2+ Exchanger Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

402.16

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective Na+/Ca2+-exchange (NCX) inhibitor; displays some selectivity for NCX1. IC50 values are 2.9, 16 and 8.6 u M for inhibition of intracellular Na+-dependent 45Ca2+ uptake by cells expressing NCX1, NCX2 and NCX3 respectively. Has some affinity for mACh receptors (IC50 = 18 u M) but minimal activity against NCKX2 and various receptors and ion channels (IC50 30 u M). Preferentially blocks Ca2+ influx mode and is more selective for NCX isoforms than KB-R7943 (Cat. No. 1244). Anti-ischemic; potently protects against hypoxia-induced renal tubular cell damage (IC50 = 0.63 u M).

catalog number base :

2184

product keywords :

Selective Na+/Ca2+ exchange inhibitors inhibits reverse mode Sodium Calcium Exchanger Ion Transporters Pumps Ca2+ Signaling Signalling NCX1 Na+/Ca2+ Exchanger 2184,

extended description :

Selective Na+/Ca2+ exchange inhibitor (reverse mode)

chemical name text :

2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester

formula :

C 20 H 22 N 2 O 5 S

formula text :

C20H22N2O5S

cas num :

415697-08-4

2020 USD :

187

2021 USD :

195 USD

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage